Thiamin phosphate synthase
From Proteopedia
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<StructureSection load='2tps' size='400' side='right' caption='Thiamin phosphate synthase complex with reaction products thiamin phosphate, pyrophosphate and Mg+2 ion (green) (PDB code [[2tps]])' scene='80/801260/Cv/1'> | <StructureSection load='2tps' size='400' side='right' caption='Thiamin phosphate synthase complex with reaction products thiamin phosphate, pyrophosphate and Mg+2 ion (green) (PDB code [[2tps]])' scene='80/801260/Cv/1'> | ||
| - | + | __TOC__ | |
== Function == | == Function == | ||
| - | '''Thiamin phosphate synthase''' (TPS) catalyzes the synthesisd of 4-methyl-5 (β-hydroxyethyl)thiazole phosphate (Thz-P) amd 4-amino-5(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to produce thiamin phosphate and pyrophosphate<ref>PMID:11513588</ref>. | + | '''Thiamin phosphate synthase''' (TPS) or '''thiamin-phosphate pyrophosphorylase''' catalyzes the synthesisd of 4-methyl-5 (β-hydroxyethyl)thiazole phosphate (Thz-P) amd 4-amino-5(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to produce thiamin phosphate and pyrophosphate<ref>PMID:11513588</ref>. |
== Relevance == | == Relevance == | ||
| - | Thiamin is an essential component of human diet. Thiamin deficiency is associated with neurodegenerative diseases<ref>PMID:19087359</ref>, delirium<ref>PMID:23696956</ref>, obesity<ref>PMID:25770253</ref> and results in beriberi<ref>PMID:25781926</ref> and in the alcoholic brain disease Korsakoff's syndrome<ref>PMID:10487391</ref>. | + | Thiamin is an essential component of human diet. Thiamin deficiency is associated with neurodegenerative diseases<ref>PMID:19087359</ref>, delirium<ref>PMID:23696956</ref>, obesity<ref>PMID:25770253</ref> and results in beriberi<ref>PMID:25781926</ref> and in the alcoholic brain disease Korsakoff's syndrome<ref>PMID:10487391</ref>. TPS is involved in thiamin biosynthesis. |
== Structural highlights == | == Structural highlights == | ||
| - | The active site pocket of TPS is formed by three loop regions. | + | The <scene name='80/801260/Cv/11'>active site pocket of TPS is formed by three loop regions</scene>. TPS reaction products thiamin phosphate and pyrophosphate interact with various residues of the protein as well as with each other<ref>PMID:10350464</ref>. |
| - | + | *<scene name='80/801260/Cv/12'>Active site pocket</scene>. | |
| - | </ | + | *<scene name='80/801260/Cv/13'>Mg coordination site</scene>. Water molecules are shown as red spheres. |
| + | *<scene name='80/801260/Cv/14'>Pyrophosphate binding site</scene>. | ||
| + | *<scene name='80/801260/Cv/15'>Thiamin phosphate binding site</scene>. | ||
| + | *<scene name='80/801260/Cv/16'>Whole active site</scene>. | ||
==3D structures of thiamin phosphate synthase== | ==3D structures of thiamin phosphate synthase== | ||
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[[3o63]] - TPS + Pi - ''Mycobacterium tuberculosis''<br /> | [[3o63]] - TPS + Pi - ''Mycobacterium tuberculosis''<br /> | ||
[[1xi3]] - TPS - ''Pyrococcus furiosus''<br /> | [[1xi3]] - TPS - ''Pyrococcus furiosus''<br /> | ||
| + | [[3ceu]] - TPS - ''Bacterioides thetaiotamicron''<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| - | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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