Thiamin phosphate synthase
From Proteopedia
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<StructureSection load='2tps' size='400' side='right' caption='Thiamin phosphate synthase complex with reaction products thiamin phosphate, pyrophosphate and Mg+2 ion (green) (PDB code [[2tps]])' scene='80/801260/Cv/1'> | <StructureSection load='2tps' size='400' side='right' caption='Thiamin phosphate synthase complex with reaction products thiamin phosphate, pyrophosphate and Mg+2 ion (green) (PDB code [[2tps]])' scene='80/801260/Cv/1'> | ||
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== Function == | == Function == | ||
| - | '''Thiamin phosphate synthase''' (TPS) catalyzes the synthesisd of 4-methyl-5 (β-hydroxyethyl)thiazole phosphate (Thz-P) amd 4-amino-5(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to produce thiamin phosphate and pyrophosphate<ref>PMID:11513588</ref>. | + | '''Thiamin phosphate synthase''' (TPS) or '''thiamin-phosphate pyrophosphorylase''' catalyzes the synthesisd of 4-methyl-5 (β-hydroxyethyl)thiazole phosphate (Thz-P) amd 4-amino-5(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to produce thiamin phosphate and pyrophosphate<ref>PMID:11513588</ref>. |
== Relevance == | == Relevance == | ||
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*<scene name='80/801260/Cv/15'>Thiamin phosphate binding site</scene>. | *<scene name='80/801260/Cv/15'>Thiamin phosphate binding site</scene>. | ||
*<scene name='80/801260/Cv/16'>Whole active site</scene>. | *<scene name='80/801260/Cv/16'>Whole active site</scene>. | ||
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| - | </StructureSection> | ||
==3D structures of thiamin phosphate synthase== | ==3D structures of thiamin phosphate synthase== | ||
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[[3o63]] - TPS + Pi - ''Mycobacterium tuberculosis''<br /> | [[3o63]] - TPS + Pi - ''Mycobacterium tuberculosis''<br /> | ||
[[1xi3]] - TPS - ''Pyrococcus furiosus''<br /> | [[1xi3]] - TPS - ''Pyrococcus furiosus''<br /> | ||
| + | [[3ceu]] - TPS - ''Bacterioides thetaiotamicron''<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| - | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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