Thyroid hormone receptor
From Proteopedia
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| - | <StructureSection load='1xzx' size='350' side='right' caption='Structure of human thyroid hormone receptor ligand-binding domain complex with thyroid hormone and cacodylate (PDB entry [[1xzx]])' scene=''> | + | <StructureSection load='1xzx' size='350' side='right' caption='Structure of human thyroid hormone receptor ligand-binding domain complex with thyroid hormone and cacodylate (PDB entry [[1xzx]])' scene='78/781020/Cv/1'> |
== Function == | == Function == | ||
'''Thyroid hormone receptors''' (TR) are expressed as 2 proteins: TRα and TRβ. TR is a ligand-dependent transcription factor that mediates the biological activity of the thyroid hormone (triiodo-thyronine). TR contains DNA-binding domain at the center and ligand-binding domain at the C-terminal. | '''Thyroid hormone receptors''' (TR) are expressed as 2 proteins: TRα and TRβ. TR is a ligand-dependent transcription factor that mediates the biological activity of the thyroid hormone (triiodo-thyronine). TR contains DNA-binding domain at the center and ligand-binding domain at the C-terminal. | ||
| + | *'''Thyroid hormone receptor alpha1''' is involved in brain functions. Its deletion is leading to severe anxiety and morphological changes in the hippocampus<ref>PMID:17315033</ref>. | ||
| + | *'''Thyroid hormone receptor beta1''' has a role as inhibitor of tutor progression and metastasis suppressor<ref>PMID:19147563</ref>. | ||
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| + | See also [[Intracellular receptors]] | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | </ | + | The <scene name='78/781020/Cv/3'>thyroid hormone binds in the ligand niche making several interactions with TR</scene><ref>PMID:15466465</ref>. |
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== 3D Structures of thyroid hormone receptor == | == 3D Structures of thyroid hormone receptor == | ||
| - | + | [[Thyroid hormone receptor 3D structures]] | |
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| - | **[[1nav]] – hTR a1 LBD + agonist - human<br /> | ||
| - | **[[4lnw]], [[2h77]], [[2h79]] – hTR a1 LBD + triiodo-thyronine<br /> | ||
| - | **[[4lnx]] – hTR a1 LBD + triiodo-thyronine + tetraiodo-thyronine <br /> | ||
| - | **[[3hzf]], [[3ilz]], [[3jzb]] – hTR a1 LBD + thyromimetic<br /> | ||
| - | **[[3uvv]] – hTR a1 LBD + retinoic acid receptor + retinoic acid + triiodo-thyronine <br /> | ||
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| - | *Thyroid hormone receptor β1 LBD residues 202-461 | ||
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| - | **[[1nq2]], [[1nuo]], [[1nq0]], [[1nq1]], [[3d57]] – hTR b1 LBD (mutant) + triiodothyroacetic acid<br /> | ||
| - | **[[1q4x]] – hTR b1 LBD + agonist <br /> | ||
| - | **[[1xzx]], [[1y0x]], [[3gws]] – hTR b1 LBD + triiodo-thyronine <br /> | ||
| - | **[[1r6g]], [[3imy]], [[3jzc]], [[1n46]] – hTR b1 LBD + thyromimetic<br /> | ||
| - | **[[1nax]] – hTR b1 LBD + ligand<br /> | ||
| - | **[[2pin]], [[2j4a]] – hTR b1 LBD + inhibitor<br /> | ||
| - | **[[1bsx]] – hTR b1 LBD + GRIP1 peptide <br /> | ||
| - | **[[4zo1]] – hTR b1 LBD + retinoic acid receptor + NCOA2 peptide + triiodo-thyronine <br /> | ||
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| - | *Thyroid hormone receptor β1 DBD residues 104-201 | ||
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| - | **[[3m9e]] – hTR b1 DBD + DNA<br /> | ||
| - | **[[2nll]] – hTR b1 DBD + retinoic acid receptor + DNA<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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