Thyroid hormone receptor

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'''Thyroid hormone receptors''' (TR) are expressed as 2 proteins: TRα and TRβ. TR is a ligand-dependent transcription factor that mediates the biological activity of the thyroid hormone (triiodo-thyronine). TR contains DNA-binding domain at the center and ligand-binding domain at the C-terminal.
'''Thyroid hormone receptors''' (TR) are expressed as 2 proteins: TRα and TRβ. TR is a ligand-dependent transcription factor that mediates the biological activity of the thyroid hormone (triiodo-thyronine). TR contains DNA-binding domain at the center and ligand-binding domain at the C-terminal.
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*'''Thyroid hormone receptor alpha1''' is involved in brain functions. Its deletion is leading to severe anxiety and morphological changes in the hippocampus<ref>PMID:17315033</ref>.
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*'''Thyroid hormone receptor beta1''' has a role as inhibitor of tutor progression and metastasis suppressor<ref>PMID:19147563</ref>.
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See also [[Intracellular receptors]]
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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The <scene name='78/781020/Cv/2'>thyroid hormone binds in the ligand niche making several interactions with TR</scene><ref>PMID:15466465</ref>.
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The <scene name='78/781020/Cv/3'>thyroid hormone binds in the ligand niche making several interactions with TR</scene><ref>PMID:15466465</ref>.
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</StructureSection>
 
== 3D Structures of thyroid hormone receptor ==
== 3D Structures of thyroid hormone receptor ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Thyroid hormone receptor 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Thyroid hormone receptor α1 LBD residues 148-408
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**[[1nav]] – hTR a1 LBD + agonist - human<br />
 
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**[[4lnw]], [[2h77]], [[2h79]] – hTR a1 LBD + triiodo-thyronine<br />
 
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**[[4lnx]] – hTR a1 LBD + triiodo-thyronine + tetraiodo-thyronine <br />
 
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**[[3hzf]], [[3ilz]], [[3jzb]] – hTR a1 LBD + thyromimetic<br />
 
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**[[3uvv]] – hTR a1 LBD + retinoic acid receptor + retinoic acid + triiodo-thyronine <br />
 
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*Thyroid hormone receptor β1 LBD residues 202-461
 
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**[[1nq2]], [[1nuo]], [[1nq0]], [[1nq1]], [[3d57]] – hTR b1 LBD (mutant) + triiodothyroacetic acid<br />
 
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**[[1q4x]] – hTR b1 LBD + agonist <br />
 
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**[[1xzx]], [[1y0x]], [[3gws]] – hTR b1 LBD + triiodo-thyronine <br />
 
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**[[1r6g]], [[3imy]], [[3jzc]], [[1n46]] – hTR b1 LBD + thyromimetic<br />
 
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**[[1nax]] – hTR b1 LBD + ligand<br />
 
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**[[2pin]], [[2j4a]] – hTR b1 LBD + inhibitor<br />
 
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**[[1bsx]] – hTR b1 LBD + GRIP1 peptide <br />
 
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**[[4zo1]] – hTR b1 LBD + retinoic acid receptor + NCOA2 peptide + triiodo-thyronine <br />
 
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*Thyroid hormone receptor β1 DBD residues 104-201
 
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**[[3m9e]] – hTR b1 DBD + DNA<br />
 
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**[[2nll]] – hTR b1 DBD + retinoic acid receptor + DNA<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human thyroid hormone receptor ligand-binding domain complex with thyroid hormone and cacodylate (PDB entry 1xzx)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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