Tumor necrosis factor receptor

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<StructureSection load='2q1m' size='340' side='right' caption='Structure of human TNFRSF-18 extracellular domain (PDB code [[2q1m]]).' scene=''>
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<StructureSection load='1ext' size='350' side='right' caption='Structure of human TNFR extracellular domain complex with sulfate and Mg+2 ion (green) (PDB code [[1ext]]).' scene='' pspeed='8'>
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__TOC__
== Function ==
== Function ==
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'''Tumor necrosis factor receptor''' (TNFR) or '''death receptor''' is a trimeric cytokine receptor which binds TNF. TNFR family contains several members and superfamily (TNFRSF) members. The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains. '''TNFRSF 6''' is called '''Fas'''; '''TNFRSF 10B''' is called '''Dr5'''; '''TNFRSF 21''' is called '''Dr6'''; '''TNFRSF 11A''' is called '''RANK'''; '''TNFRSF 18''' is called '''GITRL'''.
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'''Tumor necrosis factor receptor''' (TNFR) or '''death receptor''' is a trimeric cytokine receptor which binds TNF<ref>PMID:10358762</ref>. TNFR family contains several members and superfamily ('''TNFRSF''') members. <br />
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* '''TNFRSF 1''' is called '''Lymphotoxin-α or TNF-β'''<ref>PMID:20566898</ref>;<br />
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* '''TNFRSF 3''' is called '''TNFR-III''';<br />
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* '''TNFRSF 4''' is called '''OX40L receptor''';<br />
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* '''TNFRSF 5''' is called '''CD40L receptor''';<br />
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* '''TNFRSF 6''' is called '''Fas''';<br />
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* '''TNFRSF 9''' is called '''4-1BBL''';<br />
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* '''TNFRSF 10''' see [[TRAIL]];<br />
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* '''TNFRSF 10B''' is called '''Dr5''';<br />
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* '''TNFRSF 11A''' is called '''RANK''';<br />
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* '''TNFRSF 11B''' is called '''Osteoprotegerin''';<br />
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* '''TNFRSF 12''' is called '''TWEAK''';<br />
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* '''TNFRSF 12A''' is called '''TWEAKR''';<br />
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* '''TNFRSF 13B''' is called '''BAFF or sTALL-1''';<br />
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* '''TNFRSF 13C''' is called '''BAFF receptor''';<br />
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* '''TNFRSF 14''' is called '''LIGHT''';<br />
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* '''TNFRSF 16''' is called '''Low-affinity nerve growth factor receptor; p75NTR; p75 neurotrophin receptor''';<br />
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* '''TNFRSF 18''' is called '''GITRL''';<br />
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* '''TNFRSF 21''' is called '''Dr6''';<br />
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* '''TNFRSF 25''' is called '''Dr3''';<br />
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== Disease ==
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See also
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*[[Tumor necrosis factor ligand superfamily]]
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*[[Cytokine receptors]]
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*[[Receptor]]
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*[[Immune receptors]]
== Relevance ==
== Relevance ==
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TRAPS - a condition characterized by recurrent episodes of fever is associated with TNFR<ref>PMID:24609716</ref>.
== Structural highlights ==
== Structural highlights ==
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The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The <scene name='59/590824/Cv/8'>CRD domains are ca. 40 amino-acid long and contain 4-6 cysteine residues</scene>. The CRDs are involved in binding of TNF<ref>PMID:8939750</ref>. <scene name='59/590824/Cv/9'>Mg coordination site</scene>. Water molecules are shown as red spheres.
==3D structures of tumor necrosis factor receptor==
==3D structures of tumor necrosis factor receptor==
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[[Tumor necrosis factor receptor 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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===TNFR-1===
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[[1ncf]] – hTNFR-1 residues 12-172 (mutant) – human<br />
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[[1ich]] – hTNFR-1 death domain (mutant) - NMR<br />
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[[2eqp]] – hTNFR-1 residues 28-70 – NMR <br />
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[[1ext]] – hTNFR-1 extracellular domain <br />
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[[1ft4]] – hTNFR-1 extracellular domain + inhibitor<br />
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[[3on9]] – evTNFR SECRET domain – ectromelia virus<br />
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[[3ona]] – evTNFR SECRET domain + CX3CL1 <br />
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===TNFRSF-1B===
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[[3alq]] – hTNFRSF-1B extracellular domain + TNF<br />
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===TNFRSF-6 (Fas)===
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[[3thm]], [[3tje]] – hTNFRSF-6 extracellular domain + antibody<br />
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[[3ezq]] – hTNFRSF-6 Fas DD domain + FADD<br />
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[[3oq9]] – mTNFRSF-6 Fas DD domain + FADD - mouse<br />
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===TNFRSF-6B===
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[[3mhd]] – hTNFRSF-6B extracellular domain <br />
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[[4msv]] – hTNFRSF-6B extracellular domain + hTNFRSF-6 extracellular domain<br />
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[[4kgg]], [[4kgq]], [[4j6g]] – hTNFRSF-6B extracellular domain + hTNFRSF-14 extracellular domain<br />
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[[3mi8]] – hTNFRSF-6B extracellular domain + hTNFRSF-15 extracellular domain<br />
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[[3k51]] – hTNFRSF-6B cysteine-rich domain + hTNFRSF-15 extracellular domain<br />
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===TNFRSF-10B (Dr5)===
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[[2h9g]], [[4od2]], [[1za3]] – hTNFRSF-10B extracellular domain + antibody<br />
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[[1d0g]] – hTNFRSF-10B extracellular domain + apoptosis-2 ligand<br />
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[[1d4v]] – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand<br />
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===TNFRSF-11A (RANK)===
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[[3me4]] – mTNFRSF-11A extracellular domain <br />
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[[4giq]], [[3qbq]], [[3me2]] – mTNFRSF-11A extracellular domain + RANKL <br />
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===TNFRSF-12A===
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[[2rpj]] – hTNFRSF-12A cysteine-rich domain – NMR <br />
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===TNFRSF-18 (GITRL)===
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[[4db5]] – TNFRSF-18 – rabbit <br />
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[[4e4s]] – TNFRSF-18 – pika <br />
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[[4g4f]] – TNFRSF-18 – bushbaby <br />
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[[3fc0]], [[2qdn]], [[3b9i]] – mTNFRSF-18 <br />
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[[2q1m]] – hTNFRSF-18 extracellular domain <br />
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[[2r30]], [[2r32]] – hTNFRSF-18 extracellular domain (mutant) <br />
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===TNFRSF-21 (Dr6)===
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[[3u3p]], [[3u3q]], [[3u3s]], [[3u3t]], [[3u3v]] – hTNFRSF-21 cysteine-rich domain<br />
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[[2dbh]] – hTNFRSF-21 CARD-like domain - NMR<br />
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[[3qo4]] – hTNFRSF-21 residues 42-218<br />
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== References ==
== References ==

Current revision

Structure of human TNFR extracellular domain complex with sulfate and Mg+2 ion (green) (PDB code 1ext).

Drag the structure with the mouse to rotate

References

  1. ↑ Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol. 1999;17:331-67. PMID:10358762 doi:http://dx.doi.org/10.1146/annurev.immunol.17.1.331
  2. ↑ Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH. Lymphotoxin-alpha contributes to lymphangiogenesis. Blood. 2010 Sep 23;116(12):2173-82. PMID:20566898 doi:10.1182/blood-2009-12-256065
  3. ↑ Lopalco G, Rigante D, Vitale A, Frediani B, Iannone F, Cantarini L. Tumor necrosis factor receptor-associated periodic syndrome managed with the couple canakinumab-alendronate. Clin Rheumatol. 2015 Apr;34(4):807-9. doi: 10.1007/s10067-014-2556-8. Epub 2014, Mar 11. PMID:24609716 doi:http://dx.doi.org/10.1007/s10067-014-2556-8
  4. ↑ Naismith JH, Devine TQ, Kohno T, Sprang SR. Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure. 1996 Nov 15;4(11):1251-62. PMID:8939750

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Michal Harel, Alexander Berchansky

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