Ubiquitin-fold modifier
From Proteopedia
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== Function == | == Function == | ||
| - | '''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>. This attachment is called Ufmylation and requires '''Ubiquitin-like modifier activating enzyme''' ( | + | '''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>. This attachment is called Ufmylation and requires '''Ubiquitin-like modifier activating enzyme''' (Uba5) and '''Ufm1-conjugating enzyme''' (Ufc1). Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress<ref>PMID:31129212</ref>. Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER<ref>PMID:30626644</ref>. |
== Relevance == | == Relevance == | ||
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[[Ubiquitin-fold modifier 3D structures]] | [[Ubiquitin-fold modifier 3D structures]] | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Ubiquitin-fold modifier | ||
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| - | **[[5ia7]] – hUfm1 - human<br /> | ||
| - | **[[1wxs]] – hUfm1 - NMR<br /> | ||
| - | **[[5hkh]] – hUfm1 + peptide<br /> | ||
| - | **[[5iaa]] – hUfm1 + UBA5<br /> | ||
| - | **[[5l95]] – hUfm1 + UBA5 + AMP<br /> | ||
| - | **[[6h77]] – hUfm1 + UBA5 + ATP<br /> | ||
| - | **[[5xda]] – Ufm1 + Umf1-specific protease - ''Caenorhabditis elegans''<br /> | ||
| - | **[[6izg]] – Ufm1 - ''Trypanosoma brucei'' - NMR<br /> | ||
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| - | *Umf1-conjugating enzyme | ||
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| - | **[[2z6o]], [[2z6p]], [[3evx]] – hUfc1<br /> | ||
| - | **[[2k07]] – hUfc1 - NMR<br /> | ||
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| - | }} | ||
==References== | ==References== | ||
<references /> | <references /> | ||
</StructureSection> | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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