Acetyl-CoA synthase

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<StructureSection load='' size='350' side='right' scene='49/492892/Cv/8' caption='Acetyl-CoA synthase IV subunit α with Fe4S4 center complex with glycerol (stick model) and Ni+2 ions (green) [[1ru3]]'>
<StructureSection load='' size='350' side='right' scene='49/492892/Cv/8' caption='Acetyl-CoA synthase IV subunit α with Fe4S4 center complex with glycerol (stick model) and Ni+2 ions (green) [[1ru3]]'>
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__TOC__
== Function ==
== Function ==
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* '''ACS-III''' uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.<br />
* '''ACS-III''' uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.<br />
* '''ACS-IV''' catabolizes CO to CO2. <br />
* '''ACS-IV''' catabolizes CO to CO2. <br />
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ACS can form a bifunctional entity with carbon monoxide dehydrogenase ('''CODH/ACS'''). CODH/ACS is part of the Woods-Ljungdahl pathway of carbon fixation using CO and methyl group to produce acetyl-CoA.
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ACS can form a bifunctional entity with [[carbon monoxide dehydrogenase]] ('''CODH/ACS'''). CODH/ACS is part of the [[Wood-Ljungdahl pathway]] of [[Carbon Fixation|carbon fixation]] using CO and methyl group to produce acetyl-CoA.
== Structural highlights ==
== Structural highlights ==
ACS-I and ACS-II contain 5 subunits: α, β, γ, δ, ε. ACS-III is composed of 2 proteins: 2α+2β and γ+δ. ACS-IV is composed of α monomer.
ACS-I and ACS-II contain 5 subunits: α, β, γ, δ, ε. ACS-III is composed of 2 proteins: 2α+2β and γ+δ. ACS-IV is composed of α monomer.
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*<scene name='49/492892/Cv/10'>Fe4S4 center and 2 Ni+2 ions form interactions with 6 cysteine residues</scene> in Acetyl-CoA synthase IV subunit α from ''Carboxydothermus hydrogenoformans'' ([[1ru3]]).<ref>PMID:14699043</ref> Water molecules shown as red spheres.
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*<scene name='49/492892/Cv/11'>Fe4S4 center and 2 Ni+2 ions form interactions with 6 cysteine residues</scene> in Acetyl-CoA synthase IV subunit α from ''Carboxydothermus hydrogenoformans'' ([[1ru3]]).<ref>PMID:14699043</ref> Water molecules shown as red spheres.
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</StructureSection>
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==3D structures of acetyl-CoA synthase==
==3D structures of acetyl-CoA synthase==
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[[Acetyl-CoA synthase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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<b>References</b><br>
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<references/>
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*CODH/ACS bifunctional entity
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**[[1mjg]], [[1oao]], [[2z8y]], [[3i01]] – MtACS α+β + Fe4-Ni-S4 – ''Moorella thermoacetica''<br />
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**[[3i04]] - MtACS α+β + CN + Fe4-Ni-S4<br />
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**[[3git]] - MtACS α + Fe4S4<br />
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**[[3s2x]] - MtACS α C terminal + Ni<br />
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**[[2h9a]] – ChACS γ + Fe4S4 - ''Carboxydothermus hydrogenoformans''<br />
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**[[2ycl]] - ChACS γ + cobalamine + Fe4S4<br />
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**[[4c1n]] - ChACS γ + iron-sulfur cluster binding protein + Fe4S4<br />
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*ACS
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**[[1ytl]] – ACS ε – ''Archaeoglobus fulgidus''<br />
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**[[3cf4]] - ACS α+ε + CO + Fe3-Ni-S4 + Fe4S4 – ''Methanosarcina barkeri''
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*ACS-IV
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**[[1ru3]] - ChACS α + Fe4-Ni-S4
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}}
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[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

Acetyl-CoA synthase IV subunit α with Fe4S4 center complex with glycerol (stick model) and Ni+2 ions (green) 1ru3

Drag the structure with the mouse to rotate

References

  1. ↑ Svetlitchnyi V, Dobbek H, Meyer-Klaucke W, Meins T, Thiele B, Romer P, Huber R, Meyer O. A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):446-51. Epub 2003 Dec 29. PMID:14699043 doi:10.1073/pnas.0304262101

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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