Acetyl-CoA synthase
From Proteopedia
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<StructureSection load='' size='350' side='right' scene='49/492892/Cv/8' caption='Acetyl-CoA synthase IV subunit α with Fe4S4 center complex with glycerol (stick model) and Ni+2 ions (green) [[1ru3]]'> | <StructureSection load='' size='350' side='right' scene='49/492892/Cv/8' caption='Acetyl-CoA synthase IV subunit α with Fe4S4 center complex with glycerol (stick model) and Ni+2 ions (green) [[1ru3]]'> | ||
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== Function == | == Function == | ||
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* '''ACS-III''' uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.<br /> | * '''ACS-III''' uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.<br /> | ||
* '''ACS-IV''' catabolizes CO to CO2. <br /> | * '''ACS-IV''' catabolizes CO to CO2. <br /> | ||
| - | ACS can form a bifunctional entity with [[carbon monoxide dehydrogenase]] ('''CODH/ACS'''). CODH/ACS is part of the [[ | + | ACS can form a bifunctional entity with [[carbon monoxide dehydrogenase]] ('''CODH/ACS'''). CODH/ACS is part of the [[Wood-Ljungdahl pathway]] of [[Carbon Fixation|carbon fixation]] using CO and methyl group to produce acetyl-CoA. |
== Structural highlights == | == Structural highlights == | ||
Current revision
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References
- ↑ Svetlitchnyi V, Dobbek H, Meyer-Klaucke W, Meins T, Thiele B, Romer P, Huber R, Meyer O. A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):446-51. Epub 2003 Dec 29. PMID:14699043 doi:10.1073/pnas.0304262101
