1t5q

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[[Image:1t5q.gif|left|200px]]
[[Image:1t5q.gif|left|200px]]
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{{Structure
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|PDB= 1t5q |SIZE=350|CAPTION= <scene name='initialview01'>1t5q</scene>
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The line below this paragraph, containing "STRUCTURE_1t5q", creates the "Structure Box" on the page.
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{{STRUCTURE_1t5q| PDB=1t5q | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t5q OCA], [http://www.ebi.ac.uk/pdbsum/1t5q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t5q RCSB]</span>
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'''Solution Structure of GIP(1-30)amide in TFE/Water'''
'''Solution Structure of GIP(1-30)amide in TFE/Water'''
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==About this Structure==
==About this Structure==
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1T5Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5Q OCA].
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1T5Q is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5Q OCA].
==Reference==
==Reference==
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[[Category: Malthouse, J P.G.]]
[[Category: Malthouse, J P.G.]]
[[Category: Parker, J C.]]
[[Category: Parker, J C.]]
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[[Category: diabetes]]
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[[Category: Diabetes]]
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[[Category: gip]]
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[[Category: Gip]]
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[[Category: helix]]
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[[Category: Helix]]
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[[Category: molecular modelling]]
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[[Category: Molecular modelling]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: obesity]]
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[[Category: Obesity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:33:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:51:40 2008''
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Revision as of 06:33, 3 May 2008

Image:1t5q.gif

Template:STRUCTURE 1t5q

Solution Structure of GIP(1-30)amide in TFE/Water


Overview

Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray crystallography is vital to determine the three-dimensional structure of the peptide. Therefore, to understand the basic structural requirements for the biological activity of GIP, the solution structure of the major biologically active fragment, GIP(1-30)amide, was investigated by proton NMR spectroscopy and molecular modelling. The structure is characterised by a full length alpha-helical conformation between residues F(6) and A(28). This structural information could play an important role in the design of therapeutic agents based upon GIP receptor agonists.

About this Structure

1T5Q is a Single protein structure. Full crystallographic information is available from OCA.

Reference

NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide., Alana I, Hewage CM, Malthouse JP, Parker JC, Gault VA, O'Harte FP, Biochem Biophys Res Commun. 2004 Dec 3;325(1):281-6. PMID:15522230 Page seeded by OCA on Sat May 3 09:33:38 2008

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