Actinin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:02, 8 September 2024) (edit) (undo)
 
(29 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2eyi.png|left|200px|thumb|Crystal Structure of Alpha-actinin-1 [[2eyi]]]]
+
<StructureSection load='' size='350' side='right' scene='43/430017/Cv/2' caption='Alpha-actinin-1 [[2eyi]]'>
-
{{STRUCTURE_2eyi| PDB=2eyi | SIZE=400| SCENE=Actinin/Cv/1 |right|CAPTION=Alpha-actinin-1 [[2eyi]] }}
+
 +
__TOC__
 +
== Function ==
 +
[[Actinin]] attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells.<ref>PMID:18488141</ref> Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes:<br />
 +
* '''ACTN1''' encodes α-actinin-1 (aA1) which is a cytoskeletal isoform.<br />
 +
* '''ACTN2''' encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see [[Group:MUZIC:actinin2]].<br />
 +
* '''ACTN3''' encodes aA3 which anchors actin at the muscle Z-disk.<br />
 +
* '''ACTN4''' encodes aA4 which is found in the cytoplasm and is thought to be involved in metastasis. <br />
 +
* '''beta-ACTN''' regulates cell migration and gene expression through control of the cellular G-actin pool<ref>PMID:21900491</ref>.<br />
 +
== Structural highlights ==
-
 
+
Actinin contain <scene name='43/430017/Cv/3'>four 3-helix bundles</scene> which are called spectrin repeat (SR).<ref>PMID:16698282</ref> SR are found in proteins belonging to the cytoskeletal structure like spectrin and dystrophin.
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
[[Actinin]] attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells. Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes. ACTN1 encodes α-actinin-1 (aA1) which is a cytoskeletal isoform. ACTN2 encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see [[Group:MUZIC:actinin2]]. ACTN3 encodes aA3 which anchors actin at the muscle Z-disk. ACTN4 encodes aA4 which is found in the cytoplasm and is thought to be involved in metastasis. Actinins contain a 3-helix bundle which is called spectrin repeat (SR). The images at the left and at the right correspond to one representative Actinin, ''i.e.'' the crystal structure of human Alpha-actinin-1 ([[2eyi]]).
+
-
 
+
-
__NOTOC__
+
== 3D Structures of Actinin ==
== 3D Structures of Actinin ==
 +
[[Actinin 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
 
+
-
=== α-actinin-1 (aA1) ===
+
-
 
+
-
[[2eyi]], [[2eyn]] - haA1 ABD – human
+
-
 
+
-
 
+
-
=== α-actinin-2 (aA2) ===
+
-
 
+
-
[[1h8b]] – haA2 EF hands+rTitin Z-repeat – rabbit<br />
+
-
[[1hc2]], [[1quu]] – haA2 SR<br />
+
-
[[1hci]] – haA2 repeats 1-4
+
-
 
+
-
=== α-actinin-3 (aA3) ===
+
-
 
+
-
[[3lue]] – haA3+hActin <br />
+
-
[[1tjt]], [[1wku]] – haA3 ABD<br />
+
-
[[1g8x]] – aA3 1-2 repeats/myosin II heavy chain – ''Dictyostelium discoideum''
+
-
 
+
-
=== α-actinin-4 (aA4) ===
+
-
 
+
-
[[2r0o]] – haA4 ABD (mutant)<br />
+
-
[[1wlx]] – haA4 SR – NMR<br />
+
-
[[1sjj]] – aA – chicken - cryoEM
+
-
 
+
-
===β-actinin (bA)===
+
-
 
+
-
[[3aa0]], [[3aae]] – cbA + leucine-rich containing protein peptide – chicken<br />
+
-
[[3lk2]], [[3lk3]] - + leucine-rich containing protein fragment<br />
+
-
[[3aa1]] - cbA + pleckstrin peptide<br />
+
-
[[3aa6]], 3lk4 - cbA + Cd2-associated protein peptide<br />
+
-
[[3aa7]] – cbA (mutant)<br />
+
-
[[3aaa]] – cbA + myotrophin
+
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Alpha-actinin-1 2eyi

Drag the structure with the mouse to rotate

References

  1. ↑ Sjoblom B, Salmazo A, Djinovic-Carugo K. Alpha-actinin structure and regulation. Cell Mol Life Sci. 2008 Sep;65(17):2688-701. doi: 10.1007/s00018-008-8080-8. PMID:18488141 doi:http://dx.doi.org/10.1007/s00018-008-8080-8
  2. ↑ Bunnell TM, Burbach BJ, Shimizu Y, Ervasti JM. β-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell. 2011 Nov;22(21):4047-58. PMID:21900491 doi:10.1091/mbc.E11-06-0582
  3. ↑ Borrego-Diaz E, Kerff F, Lee SH, Ferron F, Li Y, Dominguez R. Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models. J Struct Biol. 2006 Aug;155(2):230-8. Epub 2006 Apr 25. PMID:16698282 doi:http://dx.doi.org/10.1016/j.jsb.2006.01.013

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Actinin"
Personal tools