Actinin

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<StructureSection load='2eyi' size='350' side='right' scene='43/430017/Cv/2' caption='Alpha-actinin-1 [[2eyi]]'>
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<StructureSection load='' size='350' side='right' scene='43/430017/Cv/2' caption='Alpha-actinin-1 [[2eyi]]'>
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__TOC__
== Function ==
== Function ==
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* '''ACTN2''' encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see [[Group:MUZIC:actinin2]].<br />
* '''ACTN2''' encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see [[Group:MUZIC:actinin2]].<br />
* '''ACTN3''' encodes aA3 which anchors actin at the muscle Z-disk.<br />
* '''ACTN3''' encodes aA3 which anchors actin at the muscle Z-disk.<br />
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* '''ACTN4''' encodes aA4 which is found in the cytoplasm and is thought to be involved in metastasis.
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* '''ACTN4''' encodes aA4 which is found in the cytoplasm and is thought to be involved in metastasis. <br />
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* '''beta-ACTN''' regulates cell migration and gene expression through control of the cellular G-actin pool<ref>PMID:21900491</ref>.<br />
== Structural highlights ==
== Structural highlights ==
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Actinin contain <scene name='43/430017/Cv/3'>four 3-helix bundles</scene> which are called spectrin repeat (SR).<ref>PMID:16698282</ref> SR are found in proteins belonging to the cytoskeletal structure like spectrin and dystrophin.
Actinin contain <scene name='43/430017/Cv/3'>four 3-helix bundles</scene> which are called spectrin repeat (SR).<ref>PMID:16698282</ref> SR are found in proteins belonging to the cytoskeletal structure like spectrin and dystrophin.
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</StructureSection>
 
== 3D Structures of Actinin ==
== 3D Structures of Actinin ==
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[[Actinin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* α-actinin-1 (aA1)
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**[[2eyi]], [[2eyn]] - haA1 ABD – human<br />
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**[[2n8y]], [[2n8z]] - haA1 EF hands domains 1-2 - NMR<br />
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* α-actinin-2 (aA2)
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**[[1h8b]] – haA2 EF hands+rTitin Z-repeat – rabbit<br />
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**[[1hc1]], [[1quu]] – haA2 SR<br />
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**[[1hci]] – haA2 repeats 1-4<br />
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**[[4d1e]] – haA2<br />
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**[[5a37]], [[5a38]], [[5a4b]] – haA2 calponin homology domain (mutant)<br />
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* α-actinin-3 (aA3)
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**[[3lue]] – haA3+hActin <br />
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**[[1tjt]], [[1wku]] – haA3 ABD<br />
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**[[1g8x]] – aA3 1-2 repeats/myosin II heavy chain – ''Dictyostelium discoideum''
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* α-actinin-4 (aA4)
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**[[2r0o]] – haA4 ABD (mutant)<br />
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**[[1wlx]] – haA4 SR – NMR<br />
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**[[1sjj]] – aA – chicken - cryoEM<br />
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**[[1ydi]] – haA4 vinculin-binding site + vinculin<br />
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*β-actinin (bA)
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**[[3aa0]], [[3aae]] – cbA + leucine-rich containing protein peptide – chicken<br />
 
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**[[3lk2]], [[3lk3]] - + leucine-rich containing protein fragment<br />
 
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**[[3aa1]] - cbA + pleckstrin peptide<br />
 
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**[[3aa6]], 3lk4 - cbA + Cd2-associated protein peptide<br />
 
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**[[3aa7]] – cbA (mutant)<br />
 
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**[[3aaa]] – cbA + myotrophin
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Alpha-actinin-1 2eyi

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References

  1. ↑ Sjoblom B, Salmazo A, Djinovic-Carugo K. Alpha-actinin structure and regulation. Cell Mol Life Sci. 2008 Sep;65(17):2688-701. doi: 10.1007/s00018-008-8080-8. PMID:18488141 doi:http://dx.doi.org/10.1007/s00018-008-8080-8
  2. ↑ Bunnell TM, Burbach BJ, Shimizu Y, Ervasti JM. β-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell. 2011 Nov;22(21):4047-58. PMID:21900491 doi:10.1091/mbc.E11-06-0582
  3. ↑ Borrego-Diaz E, Kerff F, Lee SH, Ferron F, Li Y, Dominguez R. Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models. J Struct Biol. 2006 Aug;155(2):230-8. Epub 2006 Apr 25. PMID:16698282 doi:http://dx.doi.org/10.1016/j.jsb.2006.01.013

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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