9evd
From Proteopedia
(Difference between revisions)
m (Protected "9evd" [edit=sysop:move=sysop]) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==In situ structure of the peripheral stalk of the mitochondrial ATPsynthase in whole Polytomella cells== | |
| + | <StructureSection load='9evd' size='340' side='right'caption='[[9evd]], [[Resolution|resolution]] 5.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9evd]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Polytomella_sp._Pringsheim_198.80 Polytomella sp. Pringsheim 198.80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EVD FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.6Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9evd OCA], [https://pdbe.org/9evd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9evd RCSB], [https://www.ebi.ac.uk/pdbsum/9evd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9evd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A5H1ZR95_9CHLO A0A5H1ZR95_9CHLO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cells depend on a continuous supply of adenosine triphosphate (ATP), the universal energy currency. In mitochondria, ATP is produced by a series of redox reactions, whereby an electrochemical gradient is established across the inner mitochondrial membrane. The ATP synthase harnesses the energy of the gradient to generate ATP from adenosine diphosphate (ADP) and inorganic phosphate. We determined the structure of ATP synthase within mitochondria of the unicellular flagellate Polytomella by electron cryo-tomography and subtomogram averaging at up to 4.2-angstrom resolution, revealing six rotary positions of the central stalk, subclassified into 21 substates of the F(1) head. The Polytomella ATP synthase forms helical arrays with multiple adjacent rows defining the cristae ridges. The structure of ATP synthase under native operating conditions in the presence of a membrane potential represents a pivotal step toward the analysis of membrane protein complexes in situ. | ||
| - | + | In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells.,Dietrich L, Agip AA, Kunz C, Schwarz A, Kuhlbrandt W Science. 2024 Sep 6;385(6713):1086-1090. doi: 10.1126/science.adp4640. Epub 2024 , Sep 5. PMID:39236170<ref>PMID:39236170</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 9evd" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Polytomella sp. Pringsheim 198 80]] | ||
| + | [[Category: Agip ANA]] | ||
| + | [[Category: Dietrich L]] | ||
| + | [[Category: Kuehlbrandt W]] | ||
Current revision
In situ structure of the peripheral stalk of the mitochondrial ATPsynthase in whole Polytomella cells
| |||||||||||
