2per

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{{STRUCTURE_2per| PDB=2per | SCENE= }}
 
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===Crystal Structure of Human Chloride Intracellular Channel protein 2===
 
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==Disease==
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==Crystal Structure of Human Chloride Intracellular Channel protein 2==
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[[http://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN]] Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure.
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<StructureSection load='2per' size='340' side='right'caption='[[2per]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[2per]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PER FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.<ref>PMID:15147738</ref><ref>PMID:15916532</ref><ref>PMID:17945253</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MNB:5-MERCAPTO-2-NITRO-BENZOIC+ACID'>MNB</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2per FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2per OCA], [https://pdbe.org/2per PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2per RCSB], [https://www.ebi.ac.uk/pdbsum/2per PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2per ProSAT]</span></td></tr>
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[[2per]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PER OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN] Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure.
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== Function ==
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[https://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.<ref>PMID:15147738</ref> <ref>PMID:15916532</ref> <ref>PMID:17945253</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/2per_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2per ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018186468</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Liang, Y H.]]
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[[Category: Large Structures]]
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[[Category: Mi, W.]]
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[[Category: Liang YH]]
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[[Category: Su, X D.]]
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[[Category: Mi W]]
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[[Category: Clic2]]
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[[Category: Su XD]]
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[[Category: Disulfide bond]]
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[[Category: Electron transport]]
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[[Category: Gst fold]]
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Current revision

Crystal Structure of Human Chloride Intracellular Channel protein 2

PDB ID 2per

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