2per

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="2per" size="350" color="white" frame="true" align="right" spinBox="true" caption="2per, resolution 2.000&Aring;" /> '''Crystal Structure o...)
Current revision (07:45, 9 October 2024) (edit) (undo)
 
(17 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2per.jpg|left|200px]]<br /><applet load="2per" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2per, resolution 2.000&Aring;" />
 
-
'''Crystal Structure of Human Chloride Intracellular Channel protein 2'''<br />
 
-
==About this Structure==
+
==Crystal Structure of Human Chloride Intracellular Channel protein 2==
-
2PER is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MNB:'>MNB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Mnb+Binding+Site+For+Residue+A+401'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PER OCA].
+
<StructureSection load='2per' size='340' side='right'caption='[[2per]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2per]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PER FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MNB:5-MERCAPTO-2-NITRO-BENZOIC+ACID'>MNB</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2per FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2per OCA], [https://pdbe.org/2per PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2per RCSB], [https://www.ebi.ac.uk/pdbsum/2per PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2per ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN] Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.<ref>PMID:15147738</ref> <ref>PMID:15916532</ref> <ref>PMID:17945253</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/2per_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2per ConSurf].
 +
<div style="clear:both"></div>
-
==Reference==
+
==See Also==
-
The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications., Mi W, Liang YH, Li L, Su XD, Proteins. 2008 Apr;71(1):509-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18186468 18186468]
+
*[[Ion channels 3D structures|Ion channels 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Liang, Y H.]]
+
[[Category: Liang YH]]
-
[[Category: Mi, W.]]
+
[[Category: Mi W]]
-
[[Category: Su, X D.]]
+
[[Category: Su XD]]
-
[[Category: MNB]]
+
-
[[Category: clic2]]
+
-
[[Category: disulfide bond]]
+
-
[[Category: electron transport]]
+
-
[[Category: gst fold]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 5 13:21:53 2008''
+

Current revision

Crystal Structure of Human Chloride Intracellular Channel protein 2

PDB ID 2per

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2per"
Personal tools