3pip

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[[Image:3pip.png|left|200px]]
 
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==Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit==
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The line below this paragraph, containing "STRUCTURE_3pip", creates the "Structure Box" on the page.
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<StructureSection load='3pip' size='340' side='right'caption='[[3pip]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pip]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PIP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LC2:N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-DIHYDROXY-1,4,10,19-TETRAMETHYL-17,18-DIOXO-16-OXABICYCLO[13.2.2]NONADECA-3,5,9,11-TETRAEN-2-YL]-2-OXOPROPANAMIDE'>LC2</scene>, <scene name='pdbligand=LMA:LANKAMYCIN'>LMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_3pip| PDB=3pip | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pip OCA], [https://pdbe.org/3pip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pip RCSB], [https://www.ebi.ac.uk/pdbsum/3pip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pip ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL11_DEIRA RL11_DEIRA] This protein binds directly to 23S ribosomal RNA and also contacts the CTC protein (RL25).[HAMAP-Rule:MF_00736_B]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structures of the large ribosomal subunit of Deinococcus radiodurans (D50S) in complex with the antibiotic lankamycin (3.2 A) and a double antibiotic complex of lankamycin and lankacidin C (3.45 A) have been determined, in continuation of previous crystallographic studies on lankacidin-D50S complex. These two drugs have been previously reported to inhibit ribosomal function with mild synergistic effect. Lankamycin, a member of the macrolide family, binds in a similar manner to erythromycin. However, when in complex with lankacidin, lankamycin is located so that it can form interactions with lankacidin in the adjacent ribosomal binding site. When compared to the well-documented synergistic antibiotics, Streptogramins A and B, the pair of lankacidin and lankamycin bind in similar sites, the peptidyl transferase center and nascent peptide exit tunnel, respectively. Herein, we discuss the structural basis for antibiotic synergism and highlight the key factors involved in ribosomal inhibition.
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===Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit===
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Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.,Belousoff MJ, Shapira T, Bashan A, Zimmerman E, Rozenberg H, Arakawa K, Kinashi H, Yonath A Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2717-22. Epub 2011 Jan 31. PMID:21282615<ref>PMID:21282615</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pip" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21282615}}, adds the Publication Abstract to the page
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21282615 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21282615}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3pip]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIP OCA].
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==Reference==
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<ref group="xtra">PMID:21282615</ref><references group="xtra"/>
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[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Deinococcus radiodurans r1]]
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[[Category: Deinococcus radiodurans R1]]
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[[Category: Bashan, A.]]
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[[Category: Large Structures]]
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[[Category: Belousoff, M J.]]
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[[Category: Bashan A]]
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[[Category: Kinashi, H.]]
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[[Category: Belousoff MJ]]
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[[Category: Rozenberg, H.]]
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[[Category: Kinashi H]]
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[[Category: Shapira, T.]]
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[[Category: Rozenberg H]]
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[[Category: Yonath, A.]]
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[[Category: Shapira T]]
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[[Category: Zimmerman, E.]]
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[[Category: Yonath A]]
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[[Category: Zimmerman E]]

Current revision

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit

PDB ID 3pip

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