3pip

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{{Large structure}}
 
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{{STRUCTURE_3pip| PDB=3pip | SCENE= }}
 
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===Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit===
 
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{{ABSTRACT_PUBMED_21282615}}
 
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==About this Structure==
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==Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit==
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[[3pip]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIP OCA].
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<StructureSection load='3pip' size='340' side='right'caption='[[3pip]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pip]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PIP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LC2:N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-DIHYDROXY-1,4,10,19-TETRAMETHYL-17,18-DIOXO-16-OXABICYCLO[13.2.2]NONADECA-3,5,9,11-TETRAEN-2-YL]-2-OXOPROPANAMIDE'>LC2</scene>, <scene name='pdbligand=LMA:LANKAMYCIN'>LMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pip OCA], [https://pdbe.org/3pip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pip RCSB], [https://www.ebi.ac.uk/pdbsum/3pip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pip ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL11_DEIRA RL11_DEIRA] This protein binds directly to 23S ribosomal RNA and also contacts the CTC protein (RL25).[HAMAP-Rule:MF_00736_B]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structures of the large ribosomal subunit of Deinococcus radiodurans (D50S) in complex with the antibiotic lankamycin (3.2 A) and a double antibiotic complex of lankamycin and lankacidin C (3.45 A) have been determined, in continuation of previous crystallographic studies on lankacidin-D50S complex. These two drugs have been previously reported to inhibit ribosomal function with mild synergistic effect. Lankamycin, a member of the macrolide family, binds in a similar manner to erythromycin. However, when in complex with lankacidin, lankamycin is located so that it can form interactions with lankacidin in the adjacent ribosomal binding site. When compared to the well-documented synergistic antibiotics, Streptogramins A and B, the pair of lankacidin and lankamycin bind in similar sites, the peptidyl transferase center and nascent peptide exit tunnel, respectively. Herein, we discuss the structural basis for antibiotic synergism and highlight the key factors involved in ribosomal inhibition.
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==See Also==
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Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.,Belousoff MJ, Shapira T, Bashan A, Zimmerman E, Rozenberg H, Arakawa K, Kinashi H, Yonath A Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2717-22. Epub 2011 Jan 31. PMID:21282615<ref>PMID:21282615</ref>
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*[[Ribosomal protein L1|Ribosomal protein L1]]
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*[[Ribosomal protein L15|Ribosomal protein L15]]
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*[[Ribosomal protein L16|Ribosomal protein L16]]
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*[[Ribosomal protein L17|Ribosomal protein L17]]
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*[[Ribosomal protein L18|Ribosomal protein L18]]
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*[[Ribosomal protein L19|Ribosomal protein L19]]
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*[[Ribosomal protein L2|Ribosomal protein L2]]
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*[[Ribosomal protein L20|Ribosomal protein L20]]
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*[[Ribosomal protein L21|Ribosomal protein L21]]
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*[[Ribosomal protein L22|Ribosomal protein L22]]
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*[[Ribosomal protein L23|Ribosomal protein L23]]
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*[[Ribosomal protein L24|Ribosomal protein L24]]
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*[[Ribosomal protein L25|Ribosomal protein L25]]
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*[[Ribosomal protein L27|Ribosomal protein L27]]
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*[[Ribosomal protein L28|Ribosomal protein L28]]
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*[[Ribosomal protein L29|Ribosomal protein L29]]
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*[[Ribosomal protein L3|Ribosomal protein L3]]
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*[[Ribosomal protein L30|Ribosomal protein L30]]
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*[[Ribosomal protein L32|Ribosomal protein L32]]
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*[[Ribosomal protein L33|Ribosomal protein L33]]
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*[[Ribosomal protein L34|Ribosomal protein L34]]
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*[[Ribosomal protein L35|Ribosomal protein L35]]
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*[[Ribosomal protein L36|Ribosomal protein L36]]
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*[[Ribosomal protein L4|Ribosomal protein L4]]
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*[[Ribosomal protein L5|Ribosomal protein L5]]
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*[[Ribosomal protein L6|Ribosomal protein L6]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:021282615</ref><references group="xtra"/>
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</div>
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<div class="pdbe-citations 3pip" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Deinococcus radiodurans r1]]
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[[Category: Deinococcus radiodurans R1]]
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[[Category: Bashan, A.]]
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[[Category: Large Structures]]
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[[Category: Belousoff, M J.]]
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[[Category: Bashan A]]
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[[Category: Kinashi, H.]]
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[[Category: Belousoff MJ]]
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[[Category: Rozenberg, H.]]
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[[Category: Kinashi H]]
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[[Category: Shapira, T.]]
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[[Category: Rozenberg H]]
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[[Category: Yonath, A.]]
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[[Category: Shapira T]]
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[[Category: Zimmerman, E.]]
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[[Category: Yonath A]]
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[[Category: 50]]
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[[Category: Zimmerman E]]
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[[Category: Lankacidin]]
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[[Category: Lankamycin]]
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[[Category: Large ribosomal subunit]]
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[[Category: Macrolide]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome]]
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[[Category: Ribosome-antibiotic complex]]
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[[Category: Rna-binding]]
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[[Category: Rrna-binding]]
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[[Category: Trna-binding]]
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Current revision

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit

PDB ID 3pip

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