1th0

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[[Image:1th0.gif|left|200px]]
[[Image:1th0.gif|left|200px]]
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{{Structure
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|PDB= 1th0 |SIZE=350|CAPTION= <scene name='initialview01'>1th0</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1th0", creates the "Structure Box" on the page.
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|SITE=
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|GENE= SENP2, KIAA1331 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1th0| PDB=1th0 | SCENE= }}
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|RELATEDENTRY=[[1tgz|1TGZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1th0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1th0 OCA], [http://www.ebi.ac.uk/pdbsum/1th0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1th0 RCSB]</span>
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'''Structure of human Senp2'''
'''Structure of human Senp2'''
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[[Category: Lima, C D.]]
[[Category: Lima, C D.]]
[[Category: Reverter, D.]]
[[Category: Reverter, D.]]
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[[Category: axam]]
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[[Category: Axam]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: senp]]
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[[Category: Senp]]
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[[Category: sumo]]
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[[Category: Sumo]]
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[[Category: ulp]]
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[[Category: Ulp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:56:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:55:53 2008''
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Revision as of 06:56, 3 May 2008

Image:1th0.gif

Template:STRUCTURE 1th0

Structure of human Senp2


Overview

Modification of cellular proteins by the ubiquitin-like protein SUMO is essential for nuclear metabolism and cell cycle progression in yeast. X-ray structures of the human Senp2 catalytic protease domain and of a covalent thiohemiacetal transition-state complex obtained between the Senp2 catalytic domain and SUMO-1 revealed details of the respective protease and substrate surfaces utilized in interactions between these two proteins. Comparative biochemical and structural analysis between Senp2 and the yeast SUMO protease Ulp1 revealed differential abilities to process SUMO-1, SUMO-2, and SUMO-3 in maturation and deconjugation reactions. Further biochemical characterization of the three SUMO isoforms into which an additional Gly-Gly di-peptide was inserted, or whereby the respective SUMO tails from the three isoforms were swapped, suggests a strict dependence for SUMO isopeptidase activity on residues C-terminal to the conserved Gly-Gly motif and preferred cleavage site for SUMO proteases.

About this Structure

1TH0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex., Reverter D, Lima CD, Structure. 2004 Aug;12(8):1519-31. PMID:15296745 Page seeded by OCA on Sat May 3 09:56:18 2008

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