1fcg

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(New page: 200px<br /> <applet load="1fcg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fcg, resolution 2.0&Aring;" /> '''ECTODOMAIN OF HUMAN ...)
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[[Image:1fcg.gif|left|200px]]<br />
 
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<applet load="1fcg" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1fcg, resolution 2.0&Aring;" />
 
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'''ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA'''<br />
 
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==Overview==
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==ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA==
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Fc gamma receptors bind IgG to initiate cellular responses against, pathogens and soluble antigens. We have determined the three-dimensional, structure of the extracellular portion of human Fc gammaRIIa to 2.0 A, resolution providing a structural basis for the unique functions of the, leukocyte FcR family. The receptor is composed of two immunoglobulin, domains and arranged to expose the ligand-binding site at one end of, domain 2. Using alanine mutants we find that the binding sites for IgG1, and 2 are similar but the relative importance of specific regions on the, receptor varies. In crystals, Fc gammaRIIa molecules associate to resemble, V(L)V(H) dimers, suggesting that two Fc gammaRIIa molecules could, cooperate to bind IgG in an asymmetric manner.
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<StructureSection load='1fcg' size='340' side='right'caption='[[1fcg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fcg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FCG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fcg OCA], [https://pdbe.org/1fcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fcg RCSB], [https://www.ebi.ac.uk/pdbsum/1fcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fcg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FCG2A_HUMAN FCG2A_HUMAN] Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.<ref>PMID:19011614</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/1fcg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fcg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fc gamma receptors bind IgG to initiate cellular responses against pathogens and soluble antigens. We have determined the three-dimensional structure of the extracellular portion of human Fc gammaRIIa to 2.0 A resolution providing a structural basis for the unique functions of the leukocyte FcR family. The receptor is composed of two immunoglobulin domains and arranged to expose the ligand-binding site at one end of domain 2. Using alanine mutants we find that the binding sites for IgG1 and 2 are similar but the relative importance of specific regions on the receptor varies. In crystals, Fc gammaRIIa molecules associate to resemble V(L)V(H) dimers, suggesting that two Fc gammaRIIa molecules could cooperate to bind IgG in an asymmetric manner.
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==Disease==
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Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa.,Maxwell KF, Powell MS, Hulett MD, Barton PA, McKenzie IF, Garrett TP, Hogarth PM Nat Struct Biol. 1999 May;6(5):437-42. PMID:10331870<ref>PMID:10331870</ref>
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Known diseases associated with this structure: Lupus nephritis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=146790 146790]]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1FCG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FCG OCA].
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</div>
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<div class="pdbe-citations 1fcg" style="background-color:#fffaf0;"></div>
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==Reference==
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== References ==
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Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa., Maxwell KF, Powell MS, Hulett MD, Barton PA, McKenzie IF, Garrett TP, Hogarth PM, Nat Struct Biol. 1999 May;6(5):437-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10331870 10331870]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Garrett, T.P.]]
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[[Category: Garrett TP]]
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[[Category: Hogarth, P.M.]]
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[[Category: Hogarth PM]]
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[[Category: Maxwell, K.F.]]
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[[Category: Maxwell KF]]
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[[Category: Powell, M.S.]]
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[[Category: Powell MS]]
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[[Category: cd32]]
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[[Category: fc receptor]]
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[[Category: immunogloulin]]
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[[Category: leukocyte]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:51:27 2007''
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Current revision

ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA

PDB ID 1fcg

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