1fzv

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==THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION==
==THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION==
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<StructureSection load='1fzv' size='340' side='right' caption='[[1fzv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='1fzv' size='340' side='right'caption='[[1fzv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1fzv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FZV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1fzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FZV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vpf|2vpf]], [[1flt|1flt]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzv OCA], [http://pdbe.org/1fzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fzv RCSB], [http://www.ebi.ac.uk/pdbsum/1fzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fzv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzv OCA], [https://pdbe.org/1fzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fzv RCSB], [https://www.ebi.ac.uk/pdbsum/1fzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fzv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PLGF_HUMAN PLGF_HUMAN]] Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.<ref>PMID:21215706</ref>
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[https://www.uniprot.org/uniprot/PLGF_HUMAN PLGF_HUMAN] Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.<ref>PMID:21215706</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fz/1fzv_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fz/1fzv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acharya, K R]]
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[[Category: Homo sapiens]]
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[[Category: Battisti, M]]
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[[Category: Large Structures]]
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[[Category: Iyer, S]]
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[[Category: Acharya KR]]
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[[Category: Leonidas, D D]]
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[[Category: Battisti M]]
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[[Category: Maglione, D]]
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[[Category: Iyer S]]
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[[Category: Persico, M G]]
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[[Category: Leonidas DD]]
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[[Category: Swaminathan, G J]]
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[[Category: Maglione D]]
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[[Category: Tucci, M]]
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[[Category: Persico MG]]
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[[Category: Angiogenesis]]
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[[Category: Swaminathan GJ]]
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[[Category: Cysteine-knot family]]
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[[Category: Tucci M]]
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[[Category: Growth factor]]
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[[Category: Hormone-growth factor complex]]
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Current revision

THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION

PDB ID 1fzv

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