1m3d

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{{Seed}}
 
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[[Image:1m3d.png|left|200px]]
 
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==Structure of Type IV Collagen NC1 Domains==
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The line below this paragraph, containing "STRUCTURE_1m3d", creates the "Structure Box" on the page.
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<StructureSection load='1m3d' size='340' side='right'caption='[[1m3d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m3d]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M3D FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LU:LUTETIUM+(III)+ION'>LU</scene></td></tr>
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{{STRUCTURE_1m3d| PDB=1m3d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m3d OCA], [https://pdbe.org/1m3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m3d RCSB], [https://www.ebi.ac.uk/pdbsum/1m3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m3d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CO4A1_BOVIN CO4A1_BOVIN] Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.[UniProtKB:P02463] Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation.[UniProtKB:P02462]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m3/1m3d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m3d ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Type IV collagen, which is present in all metazoan, exists as a family of six homologous alpha(IV) chains, alpha1-alpha6, in mammals. The six chains assemble into three different triple helical protomers and self-associate as three distinct networks. The network underlies all epithelia as a component of basement membranes, which play important roles in cell adhesion, growth, differentiation, tissue repair and molecular ultrafiltration. The specificity of both protomer and network assembly is governed by amino acid sequences of the C-terminal noncollagenous (NC1) domain of each chain. In this study, the structural basis for protomer and network assembly was investigated by determining the crystal structure of the ubiquitous [(alpha1)(2).alpha2](2) NC1 hexamer of bovine lens capsule basement membrane at 2.0 A resolution. The NC1 monomer folds into a novel tertiary structure. The (alpha1)(2).alpha2 trimer is organized through the unique three-dimensional domain swapping interactions. The differences in the primary sequences of the hypervariable region manifest in different secondary structures, which determine the chain specificity at the monomer-monomer interfaces. The trimer-trimer interface is stabilized by the extensive hydrophobic and hydrophilic interactions without a need for disulfide cross-linking.
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===Structure of Type IV Collagen NC1 Domains===
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Crystal structure of NC1 domains. Structural basis for type IV collagen assembly in basement membranes.,Sundaramoorthy M, Meiyappan M, Todd P, Hudson BG J Biol Chem. 2002 Aug 23;277(34):31142-53. Epub 2002 Apr 22. PMID:11970952<ref>PMID:11970952</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1m3d" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11970952}}, adds the Publication Abstract to the page
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*[[Collagen 3D structures|Collagen 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11970952 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11970952}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1M3D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M3D OCA].
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==Reference==
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Crystal structure of NC1 domains. Structural basis for type IV collagen assembly in basement membranes., Sundaramoorthy M, Meiyappan M, Todd P, Hudson BG, J Biol Chem. 2002 Aug 23;277(34):31142-53. Epub 2002 Apr 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11970952 11970952]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Hudson, B G.]]
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[[Category: Hudson BG]]
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[[Category: Meiyappan, M.]]
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[[Category: Meiyappan M]]
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[[Category: Sundaramoorthy, M.]]
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[[Category: Sundaramoorthy M]]
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[[Category: Todd, P.]]
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[[Category: Todd P]]
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[[Category: 3d domain swapping]]
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[[Category: Basement membrane]]
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[[Category: Br-mad]]
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[[Category: Nc1 domain]]
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[[Category: Network assembly]]
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[[Category: Type iv collagen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:07:53 2008''
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Current revision

Structure of Type IV Collagen NC1 Domains

PDB ID 1m3d

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