1of3

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[[Image:1of3.png|left|200px]]
 
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{{STRUCTURE_1of3| PDB=1of3 | SCENE= }}
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==Structural and thermodynamic dissection of specific mannan recognition by a carbohydrate-binding module, TmCBM27==
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<StructureSection load='1of3' size='340' side='right'caption='[[1of3]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1of3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OF3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1of3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1of3 OCA], [https://pdbe.org/1of3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1of3 RCSB], [https://www.ebi.ac.uk/pdbsum/1of3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1of3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9RIK9_THEMT Q9RIK9_THEMT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/of/1of3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1of3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The C-terminal 176 amino acids of a Thermotoga maritima mannanase (Man5) constitute a carbohydrate binding module (CBM) that has been classified into CBM family 27. The isolated CBM27 domain, named TmCBM27, binds tightly (K(a)s 10(5)-10(6) M(-1)) to beta-1, 4-mannooligosaccharides, carob galactomannan, and konjac glucomannan, but not to cellulose (insoluble and soluble) or soluble birchwood xylan. The X-ray crystal structures of native TmCBM27, a TmCBM27-mannohexaose complex, and a TmCBM27-6(3),6(4)-alpha-D-galactosyl-mannopentaose complex at 2.0 A, 1.6 A, and 1.35 A, respectively, reveal the basis of TmCBM27's specificity for mannans. In particular, the latter complex, which is the first structure of a CBM in complex with a branched plant cell wall polysaccharide, illustrates how the architecture of the binding site can influence the recognition of naturally substituted polysaccharides.
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===STRUCTURAL AND THERMODYNAMIC DISSECTION OF SPECIFIC MANNAN RECOGNITION BY A CARBOHYDRATE-BINDING MODULE, TMCBM27===
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Structural and thermodynamic dissection of specific mannan recognition by a carbohydrate binding module, TmCBM27.,Boraston AB, Revett TJ, Boraston CM, Nurizzo D, Davies GJ Structure. 2003 Jun;11(6):665-75. PMID:12791255<ref>PMID:12791255</ref>
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{{ABSTRACT_PUBMED_12791255}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1of3" style="background-color:#fffaf0;"></div>
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[[1of3]] is a 2 chain structure of [[Mannosidase]] with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OF3 OCA].
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==See Also==
==See Also==
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*[[Mannosidase|Mannosidase]]
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*[[Mannosidase 3D structures|Mannosidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012791255</ref><references group="xtra"/>
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__TOC__
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[[Category: Thermotoga maritima]]
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</StructureSection>
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[[Category: Boraston, A B.]]
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[[Category: Large Structures]]
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[[Category: Boraston, C M.]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Davies, G J.]]
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[[Category: Boraston AB]]
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[[Category: Nurizzo, D.]]
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[[Category: Boraston CM]]
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[[Category: Revett, T J.]]
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[[Category: Davies GJ]]
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[[Category: Carbohydrate binding module]]
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[[Category: Nurizzo D]]
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[[Category: Hydrolase]]
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[[Category: Revett TJ]]
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[[Category: Hydrolase-carbohydrate binding complex]]
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[[Category: Hydrolase/carbohydrate binding]]
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[[Category: Mannan binding]]
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[[Category: Polysaccharide degradation]]
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[[Category: Tmcbm27]]
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Current revision

Structural and thermodynamic dissection of specific mannan recognition by a carbohydrate-binding module, TmCBM27

PDB ID 1of3

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