1oi0

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[[Image:1oi0.gif|left|200px]]<br /><applet load="1oi0" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1oi0, resolution 1.5&Aring;" />
 
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'''CRYSTAL STRUCTURE OF AF2198, A JAB1/MPN DOMAIN PROTEIN FROM ARCHAEOGLOBUS FULGIDUS'''<br />
 
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==About this Structure==
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==CRYSTAL STRUCTURE OF AF2198, A JAB1/MPN DOMAIN PROTEIN FROM ARCHAEOGLOBUS FULGIDUS==
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1OI0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=144:'>144</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:144+Binding+Site+For+Chain+D'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OI0 OCA].
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<StructureSection load='1oi0' size='340' side='right'caption='[[1oi0]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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[[Category: Archaeoglobus fulgidus]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1oi0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OI0 FirstGlance]. <br>
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[[Category: Allen, M.D.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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[[Category: Bycroft, M.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Lowe, J.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oi0 OCA], [https://pdbe.org/1oi0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oi0 RCSB], [https://www.ebi.ac.uk/pdbsum/1oi0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oi0 ProSAT]</span></td></tr>
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[[Category: Tran, H.J.T.T.]]
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</table>
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[[Category: 144]]
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== Function ==
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[[Category: ZN]]
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[https://www.uniprot.org/uniprot/O28085_ARCFU O28085_ARCFU]
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[[Category: archaea]]
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== Evolutionary Conservation ==
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[[Category: deubiquitination]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: hydrolase]]
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Check<jmol>
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[[Category: proteasome]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/1oi0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oi0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 26S proteasome is responsible for the degradation of polyubiquitinated proteins. During this process the polyubiquitin chain is removed. The identity of the proteasomal component that is responsible for this activity has not been clear, as it contains no subunits that resemble known deubiquitinating enzymes. The Jab1/MPN domain is a widespread 120 amino acid protein module found in archaea, bacteria, and eukaryotes. In eukaryotes the Jab1/MPN domain is found in subunits of several multiprotein complexes including the proteasome. Recently it has been proposed that the Jab1/MPN domain of the proteasomal subunit Rpn11 is responsible for the removal of the polyubiquitin chain from substrate proteins. Here we report the crystal structure and characterization of AF2198, a Jab1/MPN domain protein from Archaeoglobolus fulgidus. The structure reveals a fold that resembles that of cytidine deaminase and places the Jab1/MPN domain in a superfamily of metal dependent hydrolases.
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:58:21 2008''
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Structure of the Jab1/MPN domain and its implications for proteasome function.,Tran HJ, Allen MD, Lowe J, Bycroft M Biochemistry. 2003 Oct 7;42(39):11460-5. PMID:14516197<ref>PMID:14516197</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1oi0" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Archaeoglobus fulgidus]]
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[[Category: Large Structures]]
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[[Category: Allen MD]]
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[[Category: Bycroft M]]
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[[Category: Lowe J]]
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[[Category: Tran HJTT]]

Current revision

CRYSTAL STRUCTURE OF AF2198, A JAB1/MPN DOMAIN PROTEIN FROM ARCHAEOGLOBUS FULGIDUS

PDB ID 1oi0

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