1qz1

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(New page: 200px<br /><applet load="1qz1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qz1, resolution 2.0&Aring;" /> '''Crystal Structure of ...)
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[[Image:1qz1.jpg|left|200px]]<br /><applet load="1qz1" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1qz1, resolution 2.0&Aring;" />
 
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'''Crystal Structure of the Ig 1-2-3 fragment of NCAM'''<br />
 
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==Overview==
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==Crystal Structure of the Ig 1-2-3 fragment of NCAM==
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The neural cell adhesion molecule, NCAM, mediates Ca(2+)-independent, cell-cell and cell-substratum adhesion via homophilic (NCAM-NCAM) and, heterophilic (NCAM-non-NCAM molecules) binding. NCAM plays a key role in, neural development, regeneration, and synaptic plasticity, including, learning and memory consolidation. The crystal structure of a fragment, comprising the three N-terminal Ig modules of rat NCAM has been determined, to 2.0 A resolution. Based on crystallographic data and biological, experiments we present a novel model for NCAM homophilic binding. The Ig1, and Ig2 modules mediate dimerization of NCAM molecules situated on the, same cell surface (cis interactions), whereas the Ig3 module mediates, interactions between NCAM molecules expressed on the surface of opposing, cells (trans interactions) through simultaneous binding to the Ig1 and Ig2, modules. This arrangement results in two perpendicular zippers forming a, double zipper-like NCAM adhesion complex.
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<StructureSection load='1qz1' size='340' side='right'caption='[[1qz1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qz1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZ1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz1 OCA], [https://pdbe.org/1qz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qz1 RCSB], [https://www.ebi.ac.uk/pdbsum/1qz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAM1_RAT NCAM1_RAT] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/1qz1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qz1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The neural cell adhesion molecule, NCAM, mediates Ca(2+)-independent cell-cell and cell-substratum adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-non-NCAM molecules) binding. NCAM plays a key role in neural development, regeneration, and synaptic plasticity, including learning and memory consolidation. The crystal structure of a fragment comprising the three N-terminal Ig modules of rat NCAM has been determined to 2.0 A resolution. Based on crystallographic data and biological experiments we present a novel model for NCAM homophilic binding. The Ig1 and Ig2 modules mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), whereas the Ig3 module mediates interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through simultaneous binding to the Ig1 and Ig2 modules. This arrangement results in two perpendicular zippers forming a double zipper-like NCAM adhesion complex.
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==About this Structure==
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Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion.,Soroka V, Kolkova K, Kastrup JS, Diederichs K, Breed J, Kiselyov VV, Poulsen FM, Larsen IK, Welte W, Berezin V, Bock E, Kasper C Structure. 2003 Oct;11(10):1291-301. PMID:14527396<ref>PMID:14527396</ref>
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1QZ1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QZ1 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion., Soroka V, Kolkova K, Kastrup JS, Diederichs K, Breed J, Kiselyov VV, Poulsen FM, Larsen IK, Welte W, Berezin V, Bock E, Kasper C, Structure. 2003 Oct;11(10):1291-301. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14527396 14527396]
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</div>
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<div class="pdbe-citations 1qz1" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Berezin V]]
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[[Category: Berezin, V.]]
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[[Category: Bock E]]
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[[Category: Bock, E.]]
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[[Category: Breed J]]
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[[Category: Breed, J.]]
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[[Category: Diederichs K]]
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[[Category: Diederichs, K.]]
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[[Category: Kasper C]]
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[[Category: Kasper, C.]]
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[[Category: Kastrup JS]]
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[[Category: Kastrup, J.S.]]
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[[Category: Kiselyov VV]]
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[[Category: Kiselyov, V.V.]]
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[[Category: Kolkova K]]
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[[Category: Kolkova, K.]]
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[[Category: Larsen IK]]
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[[Category: Larsen, I.K.]]
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[[Category: Poulsen FM]]
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[[Category: Poulsen, F.M.]]
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[[Category: Soroka V]]
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[[Category: Soroka, V.]]
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[[Category: Welte W]]
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[[Category: Welte, W.]]
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[[Category: cell adhesion]]
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[[Category: ig modules]]
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[[Category: ncam]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:08:13 2007''
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Current revision

Crystal Structure of the Ig 1-2-3 fragment of NCAM

PDB ID 1qz1

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