1u3f

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[[Image:1u3f.jpg|left|200px]]<br /><applet load="1u3f" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1u3f, resolution 2.50&Aring;" />
 
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'''Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)'''<br />
 
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==About this Structure==
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==Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)==
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1U3F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/5-formyltetrahydrofolate_cyclo-ligase 5-formyltetrahydrofolate cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.2 6.3.3.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3F OCA].
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<StructureSection load='1u3f' size='340' side='right'caption='[[1u3f]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==Reference==
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<table><tr><td colspan='2'>[[1u3f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3F FirstGlance]. <br>
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Crystal structure of methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087) at 2.2 A resolution., Chen S, Shin DH, Pufan R, Kim R, Kim SH, Proteins. 2004 Sep 1;56(4):839-43. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15281135 15281135]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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[[Category: 5-formyltetrahydrofolate cyclo-ligase]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3f OCA], [https://pdbe.org/1u3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3f RCSB], [https://www.ebi.ac.uk/pdbsum/1u3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3f ProSAT], [https://www.topsan.org/Proteins/BSGC/1u3f TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTHFS_MYCPN MTHFS_MYCPN] Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.<ref>PMID:16104022</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3f ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Mycoplasma pneumoniae]]
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[[Category: Single protein]]
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[[Category: Chen S]]
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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[[Category: Kim R]]
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[[Category: Chen, S.]]
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[[Category: Kim S-H]]
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[[Category: Kim, R.]]
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[[Category: Proudfoot M]]
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[[Category: Kim, S H.]]
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[[Category: Yakunin AF]]
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[[Category: Proudfoot, M.]]
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[[Category: Yakunin, A F.]]
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[[Category: ADP]]
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[[Category: MG]]
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[[Category: PO4]]
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[[Category: 10-methenyltetrahydrofolate synthetase; 5-formyltetrahydrofolate cyclo-ligase; mthfs; atp binding; ligase; structural genomics; bsgc structure funded by nih; protein structure initiative; psi; berkeley structural genomics center]]
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[[Category: mycoplasma pneumoniae; 5]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:20:14 2008''
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Current revision

Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)

PDB ID 1u3f

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