1wck

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(New page: 200px<br /> <applet load="1wck" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wck, resolution 1.36&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:1wck.gif|left|200px]]<br />
 
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<applet load="1wck" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1wck, resolution 1.36&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF BCLA, THE MAJOR ANTIGEN OF THE EXOSPORIUM OF THE BACILLUS ANTHRACIS SPORE.'''<br />
 
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==Overview==
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==Crystal structure of the C-terminal domain of BclA, the major antigen of the exosporium of the Bacillus anthracis spore.==
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The lethal disease anthrax is propagated by spores of Bacillus anthracis, which can penetrate into the mammalian host by inhalation, causing a rapid, progression of the disease and a mostly fatal outcome. We have solved the, three-dimensional structure of the major surface protein BclA on B., anthracis spores. Surprisingly, the structure resembles C1q, the first, component of complement, despite there being no sequence homology., Although most assays for C1q-like activity, including binding to C1q, receptors, suggest that BclA does not mimic C1q, we show that BclA, as, well as C1q, interacts with components of the lung alveolar surfactant, layer. Thus, to better recognize and invade its hosts, this pathogenic, soil bacterium may have evolved a surface protein whose structure is, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16249180 (full description)]]
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<StructureSection load='1wck' size='340' side='right'caption='[[1wck]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wck]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wck OCA], [https://pdbe.org/1wck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wck RCSB], [https://www.ebi.ac.uk/pdbsum/1wck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wck ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q83WB0_BACAN Q83WB0_BACAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wck_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wck ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The lethal disease anthrax is propagated by spores of Bacillus anthracis, which can penetrate into the mammalian host by inhalation, causing a rapid progression of the disease and a mostly fatal outcome. We have solved the three-dimensional structure of the major surface protein BclA on B. anthracis spores. Surprisingly, the structure resembles C1q, the first component of complement, despite there being no sequence homology. Although most assays for C1q-like activity, including binding to C1q receptors, suggest that BclA does not mimic C1q, we show that BclA, as well as C1q, interacts with components of the lung alveolar surfactant layer. Thus, to better recognize and invade its hosts, this pathogenic soil bacterium may have evolved a surface protein whose structure is strikingly close to a mammalian protein.
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==About this Structure==
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The crystal structure of the Bacillus anthracis spore surface protein BclA shows remarkable similarity to mammalian proteins.,Rety S, Salamitou S, Garcia-Verdugo I, Hulmes DJ, Le Hegarat F, Chaby R, Lewit-Bentley A J Biol Chem. 2005 Dec 30;280(52):43073-8. Epub 2005 Oct 25. PMID:16249180<ref>PMID:16249180</ref>
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1WCK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]] with CAC as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WCK OCA]].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The crystal structure of the Bacillus anthracis spore surface protein BclA shows remarkable similarity to mammalian proteins., Rety S, Salamitou S, Garcia-Verdugo I, Hulmes DJ, Le Hegarat F, Chaby R, Lewit-Bentley A, J Biol Chem. 2005 Dec 30;280(52):43073-8. Epub 2005 Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16249180 16249180]
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</div>
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<div class="pdbe-citations 1wck" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Augusto, L.A.]]
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[[Category: Augusto LA]]
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[[Category: Chaby, R.]]
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[[Category: Chaby R]]
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[[Category: Lehegarat, F.]]
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[[Category: Lehegarat F]]
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[[Category: Lewit-Bentley, A.]]
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[[Category: Lewit-Bentley A]]
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[[Category: Rety, S.]]
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[[Category: Rety S]]
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[[Category: Salamitou, S.]]
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[[Category: Salamitou S]]
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[[Category: CAC]]
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[[Category: bacterial surface antigen]]
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[[Category: collagen-like protein]]
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[[Category: jelly-roll topology]]
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[[Category: structural protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 15:56:00 2007''
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Current revision

Crystal structure of the C-terminal domain of BclA, the major antigen of the exosporium of the Bacillus anthracis spore.

PDB ID 1wck

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