3a0c

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[[Image:3a0c.png|left|200px]]
 
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==Crystal Structure of an anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua==
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The line below this paragraph, containing "STRUCTURE_3a0c", creates the "Structure Box" on the page.
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<StructureSection load='3a0c' size='340' side='right'caption='[[3a0c]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3a0c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Polygonatum_cyrtonema Polygonatum cyrtonema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A0C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a0c OCA], [https://pdbe.org/3a0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a0c RCSB], [https://www.ebi.ac.uk/pdbsum/3a0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a0c ProSAT]</span></td></tr>
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{{STRUCTURE_3a0c| PDB=3a0c | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8L568_9ASPA Q8L568_9ASPA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/3a0c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a0c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Polygonatum cyrtonema lectin (PCL) is a novel anti-HIV mannose-binding lectin from Galanthus nivalis agglutinin (GNA)-related lectin family. Crystal structures of ligand-free PCL and its complexes with monomannoside and alpha1-3 dimannoside have been determined. The ligand-free PCL is dimeric, with both subunits adopt the beta-prism II fold. PCL subunit binds mannose using a potential bivalent mode instead of the usual trivalent mode, in which carbohydrate-binding site (CBS) I and CBS III adopt the conserved mannose-binding motif of QXDXNXVXY (X is one of any amino acid residues) as observed in other structurally characterized GNA-related lectins, while CBS II adopts a modified motif with residues Gln58 and Asp60, which are critical for mannose-binding, substituted by His58 and Asn60, respectively. As a result, CBS II is unfit for mannose-binding. In the mannoside complexes, ligand-bindings only occur at CBS I which provides the specificity for alpha1-3 dimannoside. CBS II and CBS III are cooperatively occupied by a well-ordered sulfate ion, through which the individual dimers are cross-linked to form a unique super-structure of 3(2) helical lattice. Surveying the sequences of GNA-related lectins revealed that the modified binding motif of CBS II is widely distributed in the Liliaceae family as an intrinsic structural element. There is evidence that other GNA-related lectins will also adopt the similar super-structure as PCL. Thus PCL structure, unique in ligand-binding mode, may represent a novel type of structure of GNA-related lectins. Comparative analyses indicated that the dimer-based super-structure may play a primary role in the anti-HIV property of PCL.
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===Crystal Structure of an anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua===
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Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure.,Ding J, Bao J, Zhu D, Zhang Y, Wang DC J Struct Biol. 2010 Sep;171(3):309-17. Epub 2010 May 28. PMID:20546901<ref>PMID:20546901</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3a0c" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20546901}}, adds the Publication Abstract to the page
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*[[Mannose-binding protein|Mannose-binding protein]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20546901 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20546901}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3a0c]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Polygonatum_cyrtonema Polygonatum cyrtonema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A0C OCA].
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==Reference==
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<ref group="xtra">PMID:020546901</ref><references group="xtra"/>
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[[Category: Polygonatum cyrtonema]]
[[Category: Polygonatum cyrtonema]]
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[[Category: Ding, J.]]
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[[Category: Ding J]]
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[[Category: Wang, D C.]]
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[[Category: Wang DC]]
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[[Category: Beta-prism ii]]
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[[Category: Lectin]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal Structure of an anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua

PDB ID 3a0c

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