6eiy

<StructureSection load='6eiy' size='340' side='right' caption='[[6eiy]], [[Resolution|resolution]] 2.15&Aring;' scene=''>

<table><tr><td colspan='2'>[[6eiy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EIY FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B6W:2-chloranyl-~{N}-[2-[4-(3-cyano-7-oxidanylidene-6-propan-2-yl-4~{H}-pyrazolo[1,5-a]pyrimidin-5-yl)pyrazol-1-yl]ethyl]ethanamide'>B6W</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eiy OCA], [http://pdbe.org/6eiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eiy RCSB], [http://www.ebi.ac.uk/pdbsum/6eiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eiy ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Burgess-Brown, N A]]

[[Category: Delft, F von]]

[[Category: Edwards, A]]

[[Category: Huber, K]]

[[Category: Kupinska, K]]

[[Category: Newman, J A]]

[[Category: Oppermann, U]]

[[Category: Ruda, G F]]

[[Category: Srikannathasan, V]]

[[Category: Strain-Damerell, C]]

[[Category: Szykowska, A]]

[[Category: Vazquez-Rodriguez, S A]]

[[Category: Wright, M]]

[[Category: Kdm5b lysine specific demethylase]]

[[Category: Oxidoreductase]]