6y6c

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6y6c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y6C FirstGlance]. <br>
<table><tr><td colspan='2'>[[6y6c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y6C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y6c OCA], [https://pdbe.org/6y6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y6c RCSB], [https://www.ebi.ac.uk/pdbsum/6y6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y6c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y6c OCA], [https://pdbe.org/6y6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y6c RCSB], [https://www.ebi.ac.uk/pdbsum/6y6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y6c ProSAT]</span></td></tr>
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</table>
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== Disease ==
 
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[https://www.uniprot.org/uniprot/TREM2_HUMAN TREM2_HUMAN] Progressive non-fluent aphasia;Amyotrophic lateral sclerosis;Nasu-Hakola disease;Semantic dementia;Behavioral variant of frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry.
 
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== Function ==
 
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[https://www.uniprot.org/uniprot/TREM2_HUMAN TREM2_HUMAN] May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.<ref>PMID:10799849</ref>
 
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<div class="pdbe-citations 6y6c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6y6c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>

Current revision

TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4)

PDB ID 6y6c

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