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1tnd

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[[Image:1tnd.gif|left|200px]]
[[Image:1tnd.gif|left|200px]]
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{{Structure
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|PDB= 1tnd |SIZE=350|CAPTION= <scene name='initialview01'>1tnd</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1tnd", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GSP:5&#39;-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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{{STRUCTURE_1tnd| PDB=1tnd | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tnd OCA], [http://www.ebi.ac.uk/pdbsum/1tnd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tnd RCSB]</span>
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'''THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S'''
'''THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S'''
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[[Category: Noel, J P.]]
[[Category: Noel, J P.]]
[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
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[[Category: binding protein(gtp)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:09:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:58:29 2008''
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Revision as of 07:09, 3 May 2008

Image:1tnd.gif

Template:STRUCTURE 1tnd

THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S


Overview

The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic studies, suggests: how an activated receptor might open this cleft to allow nucleotide exchange; a mechanism for GTP-induced changes in effector and receptor binding surfaces; and a mechanism for GTPase activity not evident from previous data.

About this Structure

1TND is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S., Noel JP, Hamm HE, Sigler PB, Nature. 1993 Dec 16;366(6456):654-63. PMID:8259210 Page seeded by OCA on Sat May 3 10:09:23 2008

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