1yp9

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[[Image:1yp9.gif|left|200px]]<br /><applet load="1yp9" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1yp9, resolution 2.10&Aring;" />
 
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'''Trypsin Inhibitor Complex'''<br />
 
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==About this Structure==
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==Trypsin Inhibitor Complex==
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1YP9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=UIZ:'>UIZ</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP9 OCA].
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<StructureSection load='1yp9' size='340' side='right'caption='[[1yp9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yp9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YP9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UIZ:(1R,3AS,4R,8AS,8BR)-4-(2-BENZO[1,3]DIOXOL-5-YLMETHYL)-1-BENZYL-3-OXO-DECAHYDRO-PYRROLO[3,4-A]PYRROZILIN-4-YL-BENZAMIDINE'>UIZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp9 OCA], [https://pdbe.org/1yp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yp9 RCSB], [https://www.ebi.ac.uk/pdbsum/1yp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yp9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yp/1yp9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yp9 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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A simple protocol to estimate differences in protein binding affinity for enantiomers without prior resolution of racemates., Fokkens J, Klebe G, Angew Chem Int Ed Engl. 2006 Jan 30;45(6):985-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16374786 16374786]
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*[[Trypsin 3D structures|Trypsin 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Trypsin]]
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[[Category: Diederich F]]
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[[Category: Diederich, F.]]
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[[Category: Fokkens J]]
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[[Category: Fokkens, J.]]
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[[Category: Heine A]]
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[[Category: Heine, A.]]
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[[Category: Klebe G]]
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[[Category: Klebe, G.]]
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[[Category: Obst-Sander U]]
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[[Category: Obst-Sander, U.]]
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[[Category: CA]]
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[[Category: GOL]]
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[[Category: UIZ]]
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[[Category: 6 stranded beta-sheet]]
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[[Category: barrel]]
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[[Category: inhibitor complex]]
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[[Category: trypsin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:07:51 2008''
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Current revision

Trypsin Inhibitor Complex

PDB ID 1yp9

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