2jgr

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{{Seed}}
 
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[[Image:2jgr.png|left|200px]]
 
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==Crystal structure of YegS in complex with ADP==
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The line below this paragraph, containing "STRUCTURE_2jgr", creates the "Structure Box" on the page.
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<StructureSection load='2jgr' size='340' side='right'caption='[[2jgr]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21 Escherichia coli BL21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
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{{STRUCTURE_2jgr| PDB=2jgr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgr OCA], [https://pdbe.org/2jgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jgr RCSB], [https://www.ebi.ac.uk/pdbsum/2jgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YEGS_ECOLI YEGS_ECOLI] In vitro phosphorylates phosphatidylglycerol but not diacylglycerol; the in vivo substrate is unknown.[HAMAP-Rule:MF_01377]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The human lipid kinase family controls cell proliferation, differentiation, and tumorigenesis and includes diacylglycerol kinases, sphingosine kinases, and ceramide kinases. YegS is an Escherichia coli protein with significant sequence homology to the catalytic domain of the human lipid kinases. We have solved the crystal structure of YegS and shown that it is a lipid kinase with phosphatidylglycerol kinase activity. The crystal structure reveals a two-domain protein with significant structural similarity to a family of NAD kinases. The active site is located in the interdomain cleft formed by four conserved sequence motifs. Surprisingly, the structure reveals a novel metal binding site composed of residues conserved in most lipid kinases.
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===CRYSTAL STRUCTURE OF YEGS IN COMPLEX WITH ADP===
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Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site.,Bakali HM, Herman MD, Johnson KA, Kelly AA, Wieslander A, Hallberg BM, Nordlund P J Biol Chem. 2007 Jul 6;282(27):19644-52. Epub 2007 Mar 11. PMID:17351295<ref>PMID:17351295</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17351295}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jgr" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17351295 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17351295}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli BL21]]
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2JGR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGR OCA].
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[[Category: Large Structures]]
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[[Category: Bakali HM]]
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==Reference==
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[[Category: Hallberg BM]]
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Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site., Bakali HM, Herman MD, Johnson KA, Kelly AA, Wieslander A, Hallberg BM, Nordlund P, J Biol Chem. 2007 Jul 6;282(27):19644-52. Epub 2007 Mar 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17351295 17351295]
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[[Category: Herman MD]]
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[[Category: Escherichia coli]]
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[[Category: Johnson KA]]
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[[Category: Single protein]]
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[[Category: Kelly AA]]
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[[Category: Bakali, H M.]]
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[[Category: Nordlund P]]
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[[Category: Hallberg, B M.]]
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[[Category: Wieslander A]]
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[[Category: Herman, M D.]]
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[[Category: Johnson, K A.]]
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[[Category: Kelly, A A.]]
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[[Category: Nordlund, P.]]
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[[Category: Wieslander, A.]]
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[[Category: Hypothetical protein]]
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[[Category: Lipid kinase]]
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[[Category: Phosphatidylglycerole kinase]]
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[[Category: Pyrrophosphate]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:16:30 2008''
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Current revision

Crystal structure of YegS in complex with ADP

PDB ID 2jgr

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OCA

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