5wiu

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==Structure of the human D4 Dopamine receptor in complex with Nemonapride==
==Structure of the human D4 Dopamine receptor in complex with Nemonapride==
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<StructureSection load='5wiu' size='340' side='right' caption='[[5wiu]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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<StructureSection load='5wiu' size='340' side='right'caption='[[5wiu]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WIU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wiu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WIU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AQD:Nemonapride'>AQD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.962&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wiv|5wiv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AQD:5-chloranyl-2-methoxy-4-(methylamino)-~{N}-[(2~{R},3~{R})-2-methyl-1-(phenylmethyl)pyrrolidin-3-yl]benzamide'>AQD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DRD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wiu OCA], [https://pdbe.org/5wiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wiu RCSB], [https://www.ebi.ac.uk/pdbsum/5wiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wiu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wiu OCA], [http://pdbe.org/5wiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wiu RCSB], [http://www.ebi.ac.uk/pdbsum/5wiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wiu ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DRD4_HUMAN DRD4_HUMAN]] Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
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[https://www.uniprot.org/uniprot/DRD4_HUMAN DRD4_HUMAN] Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wiu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wiu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dopamine receptor 3D structures|Dopamine receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Betz, R M]]
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[[Category: Homo sapiens]]
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[[Category: Che, T]]
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[[Category: Large Structures]]
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[[Category: Dror, R O]]
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[[Category: Betz RM]]
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[[Category: Huang, X P]]
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[[Category: Che T]]
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[[Category: Levit, A]]
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[[Category: Dror RO]]
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[[Category: McCorvy, J D]]
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[[Category: Huang X-P]]
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[[Category: Roth, B L]]
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[[Category: Levit A]]
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[[Category: Shoichet, B K]]
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[[Category: McCorvy JD]]
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[[Category: Venkatakrishnan, A J]]
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[[Category: Roth BL]]
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[[Category: Wacker, D]]
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[[Category: Shoichet BK]]
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[[Category: Wang, S]]
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[[Category: Venkatakrishnan AJ]]
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[[Category: Antagonist]]
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[[Category: Wacker D]]
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[[Category: Dopamine receptor]]
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[[Category: Wang S]]
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[[Category: Gpcr]]
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[[Category: Signaling protein-antagonist complex]]
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[[Category: Sodium]]
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Current revision

Structure of the human D4 Dopamine receptor in complex with Nemonapride

PDB ID 5wiu

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