7yeu
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Superfolder green fluorescent protein with phosphine unnatural amino acid P3BF== | |
+ | <StructureSection load='7yeu' size='340' side='right'caption='[[7yeu]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[7yeu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YEU FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GYS:[(4Z)-2-(1-AMINO-2-HYDROXYETHYL)-4-(4-HYDROXYBENZYLIDENE)-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]ACETIC+ACID'>GYS</scene>, <scene name='pdbligand=IKJ:(2~{S})-2-azanyl-3-[4-(1-boranyl-1$l^{5}-phospholan-1-yl)phenyl]propanoic+acid'>IKJ</scene></td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yeu OCA], [https://pdbe.org/7yeu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yeu RCSB], [https://www.ebi.ac.uk/pdbsum/7yeu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yeu ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin. | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Phosphine ligands are the most important class of ligands for cross-coupling reactions due to their unique electronic and steric properties. However, metalloproteins generally rely on nitrogen, sulfur, or oxygen ligands. Here, we report the genetic incorporation of P3BF, which contains a biocompatible borane-protected phosphine, into proteins. This step is followed by a straightforward one-pot strategy to perform deboronation and palladium coordination in aqueous and aerobic conditions. The genetically encoded phosphine ligand P3BF should significantly expand our ability to design functional metalloproteins. | ||
- | + | Genetically Encoded Phosphine Ligand for Metalloprotein Design.,Duan HZ, Hu C, Li YL, Wang SH, Xia Y, Liu X, Wang J, Chen YX J Am Chem Soc. 2022 Dec 21;144(50):22831-22837. doi: 10.1021/jacs.2c09683. Epub , 2022 Nov 23. PMID:36417425<ref>PMID:36417425</ref> | |
- | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
- | [[Category: | + | </div> |
- | [[Category: Chen | + | <div class="pdbe-citations 7yeu" style="background-color:#fffaf0;"></div> |
- | [[Category: | + | == References == |
- | [[Category: | + | <references/> |
- | [[Category: | + | __TOC__ |
- | [[Category: | + | </StructureSection> |
+ | [[Category: Aequorea victoria]] | ||
+ | [[Category: Large Structures]] | ||
+ | [[Category: Chen YX]] | ||
+ | [[Category: Duan HZ]] | ||
+ | [[Category: Hu C]] | ||
+ | [[Category: Liu XH]] | ||
+ | [[Category: Wang JY]] |
Current revision
Superfolder green fluorescent protein with phosphine unnatural amino acid P3BF
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Categories: Aequorea victoria | Large Structures | Chen YX | Duan HZ | Hu C | Liu XH | Wang JY