7yeu

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'''Unreleased structure'''
 
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The entry 7yeu is ON HOLD
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==Superfolder green fluorescent protein with phosphine unnatural amino acid P3BF==
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<StructureSection load='7yeu' size='340' side='right'caption='[[7yeu]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7yeu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YEU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GYS:[(4Z)-2-(1-AMINO-2-HYDROXYETHYL)-4-(4-HYDROXYBENZYLIDENE)-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]ACETIC+ACID'>GYS</scene>, <scene name='pdbligand=IKJ:(2~{S})-2-azanyl-3-[4-(1-boranyl-1$l^{5}-phospholan-1-yl)phenyl]propanoic+acid'>IKJ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yeu OCA], [https://pdbe.org/7yeu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yeu RCSB], [https://www.ebi.ac.uk/pdbsum/7yeu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yeu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Phosphine ligands are the most important class of ligands for cross-coupling reactions due to their unique electronic and steric properties. However, metalloproteins generally rely on nitrogen, sulfur, or oxygen ligands. Here, we report the genetic incorporation of P3BF, which contains a biocompatible borane-protected phosphine, into proteins. This step is followed by a straightforward one-pot strategy to perform deboronation and palladium coordination in aqueous and aerobic conditions. The genetically encoded phosphine ligand P3BF should significantly expand our ability to design functional metalloproteins.
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Authors: Hu, C., Duan, H.Z., Liu, X.H., Chen, Y.X., Wang, J.Y.
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Genetically Encoded Phosphine Ligand for Metalloprotein Design.,Duan HZ, Hu C, Li YL, Wang SH, Xia Y, Liu X, Wang J, Chen YX J Am Chem Soc. 2022 Dec 21;144(50):22831-22837. doi: 10.1021/jacs.2c09683. Epub , 2022 Nov 23. PMID:36417425<ref>PMID:36417425</ref>
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Description: Superfolder green fluorescent protein with phosphine unnatural amino acid P3F
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Chen, Y.X]]
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<div class="pdbe-citations 7yeu" style="background-color:#fffaf0;"></div>
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[[Category: Liu, X.H]]
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== References ==
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[[Category: Wang, J.Y]]
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<references/>
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[[Category: Duan, H.Z]]
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__TOC__
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[[Category: Hu, C]]
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</StructureSection>
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[[Category: Aequorea victoria]]
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[[Category: Large Structures]]
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[[Category: Chen YX]]
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[[Category: Duan HZ]]
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[[Category: Hu C]]
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[[Category: Liu XH]]
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[[Category: Wang JY]]

Current revision

Superfolder green fluorescent protein with phosphine unnatural amino acid P3BF

PDB ID 7yeu

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