1boy

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[[Image:1boy.gif|left|200px]]<br />
 
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<applet load="1boy" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1boy, resolution 2.2&Aring;" />
 
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'''EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR'''<br />
 
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==Overview==
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==EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR==
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Tissue factor is a cell-surface glycoprotein receptor which initiates the, blood coagulation cascade after vessel injury by interacting with blood, clotting factor VII/VIIa and which is implicated in various pathological, processes. When bound to tissue factor, factor VII is readily converted to, the active protease factor VIIa by trace amounts of factors Xa, IXa or, VIIa. Human tissue factor consists of 263 residues, the first 219 of which, comprise the extracellular region. We have determined the crystal, structure of the extracellular region at a resolution of 2.2 A. Tissue, factor consists of two immunoglobulin-like domains associated through an, extensive, novel, interdomain interface region. The binding site for, factor VII lies at the interface region and involves residues from domain, 1 and an extended loop (binding 'finger') of domain 2. This is the first, reported structure of a representative of the class 2 cytokine receptor, family, which also includes interferon-alpha, interferon-gamma (refs 2, 3), and interleukin-10 (ref. 4) receptors.
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<StructureSection load='1boy' size='340' side='right'caption='[[1boy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1boy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BOY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1boy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1boy OCA], [https://pdbe.org/1boy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1boy RCSB], [https://www.ebi.ac.uk/pdbsum/1boy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1boy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/1boy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1boy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tissue factor is a cell-surface glycoprotein receptor which initiates the blood coagulation cascade after vessel injury by interacting with blood clotting factor VII/VIIa and which is implicated in various pathological processes. When bound to tissue factor, factor VII is readily converted to the active protease factor VIIa by trace amounts of factors Xa, IXa or VIIa. Human tissue factor consists of 263 residues, the first 219 of which comprise the extracellular region. We have determined the crystal structure of the extracellular region at a resolution of 2.2 A. Tissue factor consists of two immunoglobulin-like domains associated through an extensive, novel, interdomain interface region. The binding site for factor VII lies at the interface region and involves residues from domain 1 and an extended loop (binding 'finger') of domain 2. This is the first reported structure of a representative of the class 2 cytokine receptor family, which also includes interferon-alpha, interferon-gamma (refs 2, 3) and interleukin-10 (ref. 4) receptors.
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==Disease==
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Crystal structure of the extracellular region of human tissue factor.,Harlos K, Martin DM, O'Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tuddenham EG, Boys CW Nature. 1994 Aug 25;370(6491):662-6. PMID:8065454<ref>PMID:8065454</ref>
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Known disease associated with this structure: Esophageal squamous cell carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606551 606551]]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1BOY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Structure known Active Sites: 7A1, 7A2 and XA1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BOY OCA].
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</div>
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<div class="pdbe-citations 1boy" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Crystal structure of the extracellular region of human tissue factor., Harlos K, Martin DM, O'Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tuddenham EG, Boys CW, Nature. 1994 Aug 25;370(6491):662-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8065454 8065454]
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*[[Tissue factor|Tissue factor]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Boys, C.W.G.]]
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[[Category: Boys CWG]]
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[[Category: Harlos, K.]]
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[[Category: Harlos K]]
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[[Category: Tuddenham, E.G.D.]]
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[[Category: Tuddenham EGD]]
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[[Category: blood coagulation]]
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[[Category: class 2 cytokine receptor]]
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[[Category: cofactor for factor viia]]
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[[Category: glycoprotein]]
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[[Category: initiator of blood coagulation in vertebrates]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:13:09 2007''
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Current revision

EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR

PDB ID 1boy

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