1bwm

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{{Seed}}
 
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[[Image:1bwm.png|left|200px]]
 
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==A SINGLE-CHAIN T CELL RECEPTOR==
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The line below this paragraph, containing "STRUCTURE_1bwm", creates the "Structure Box" on the page.
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<StructureSection load='1bwm' size='340' side='right'caption='[[1bwm]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bwm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BWM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bwm OCA], [https://pdbe.org/1bwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bwm RCSB], [https://www.ebi.ac.uk/pdbsum/1bwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bwm ProSAT]</span></td></tr>
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{{STRUCTURE_1bwm| PDB=1bwm | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5R1G1_MOUSE Q5R1G1_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/1bwm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bwm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs) 3beta and 1alpha and surface properties of 2alpha are different from those of related class I-restricted TCRs. We infer a conserved orientation for TCR V(alpha) domains in complexes with both class I and II MHC-peptide ligands, which implies that small structural variations in V(alpha) confer MHC class preference. High mobility of CDR3 residues relative to other CDR or framework residues (picosecond time scale) provides insight into immune recognition and selection mechanisms.
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===A SINGLE-CHAIN T CELL RECEPTOR===
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Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.,Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:10360364<ref>PMID:10360364</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1bwm" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10360364}}, adds the Publication Abstract to the page
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*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10360364 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10360364}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1BWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWM OCA].
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==Reference==
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Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor., Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G, Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10360364 10360364]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Hare BJ]]
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[[Category: Hare, B J.]]
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[[Category: Reinherz EL]]
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[[Category: Reinherz, E L.]]
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[[Category: Wagner G]]
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[[Category: Wagner, G.]]
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[[Category: Wyss DF]]
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[[Category: Wyss, D F.]]
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[[Category: Immunoglobulin]]
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[[Category: Immunoreceptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:49:58 2008''
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Current revision

A SINGLE-CHAIN T CELL RECEPTOR

PDB ID 1bwm

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OCA

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