1d4n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:31, 30 October 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1d4n.png|left|200px]]
 
-
<!--
+
==HUMAN SERUM TRANSFERRIN==
-
The line below this paragraph, containing "STRUCTURE_1d4n", creates the "Structure Box" on the page.
+
<StructureSection load='1d4n' size='340' side='right'caption='[[1d4n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1d4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D4N FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-
{{STRUCTURE_1d4n| PDB=1d4n | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d4n OCA], [https://pdbe.org/1d4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d4n RCSB], [https://www.ebi.ac.uk/pdbsum/1d4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d4n ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/1d4n_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d4n ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The X-ray crystallographic structures of two mutants (K206Q and H207E) of the N-lobe of human transferrin (hTF/2N) have been determined to high resolution (1.8 and 2.0 A, respectively). Both mutant proteins bind iron with greater affinity than native hTF/2N. The structures of the K206Q and H207E mutants show interactions (both H-bonding and electrostatic) that stabilize the interaction of Lys296 in the closed conformation, thereby stabilizing the iron bound forms.
-
===HUMAN SERUM TRANSFERRIN===
+
Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron.,Yang AH, MacGillivray RT, Chen J, Luo Y, Wang Y, Brayer GD, Mason AB, Woodworth RC, Murphy ME Protein Sci. 2000 Jan;9(1):49-52. PMID:10739246<ref>PMID:10739246</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1d4n" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_10739246}}, adds the Publication Abstract to the page
+
*[[Transferrin 3D structures|Transferrin 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 10739246 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_10739246}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1D4N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D4N OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:10739246</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Brayer, G D.]]
+
[[Category: Large Structures]]
-
[[Category: Chen, J.]]
+
[[Category: Brayer GD]]
-
[[Category: Luo, Y.]]
+
[[Category: Chen J]]
-
[[Category: MacGillivray, R T.A.]]
+
[[Category: Luo Y]]
-
[[Category: Mason, A.]]
+
[[Category: MacGillivray RTA]]
-
[[Category: Murphy, M E.P.]]
+
[[Category: Mason A]]
-
[[Category: Wang, Y.]]
+
[[Category: Murphy MEP]]
-
[[Category: Woodworth, R C.]]
+
[[Category: Wang Y]]
-
[[Category: Yang, H W.]]
+
[[Category: Woodworth RC]]
-
[[Category: Carbonate]]
+
[[Category: Yang H-W]]
-
[[Category: Glycoprotein]]
+
-
[[Category: Iron transport]]
+
-
[[Category: Iron-release]]
+
-
[[Category: N-lobe]]
+
-
[[Category: Transferrin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:11:58 2009''
+

Current revision

HUMAN SERUM TRANSFERRIN

PDB ID 1d4n

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1d4n"
Personal tools