1lup

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{{Seed}}
 
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[[Image:1lup.png|left|200px]]
 
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==Solution structure of a toxin (GsMTx2) from the tarantula, Grammostola spatulata, which inhibits mechanosensitive ion channels==
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The line below this paragraph, containing "STRUCTURE_1lup", creates the "Structure Box" on the page.
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<StructureSection load='1lup' size='340' side='right'caption='[[1lup]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lup]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Grammostola_rosea Grammostola rosea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LUP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lup OCA], [https://pdbe.org/1lup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lup RCSB], [https://www.ebi.ac.uk/pdbsum/1lup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lup ProSAT]</span></td></tr>
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{{STRUCTURE_1lup| PDB=1lup | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTX2_GRARO MTX2_GRARO]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mechanosensitive channels (MSCs) play key roles in sensory processing and have been implicated as primary transducers for a variety of cellular responses ranging from osmosensing to gene expression. This paper presents the first structures of any kind known to interact specifically with MSCs. GsMTx-4 and GsMtx-2 are inhibitor cysteine knot peptides isolated from venom of the tarantula, Grammostola spatulata (Suchyna, T. M., Johnson, J. H., Hamer, K., Leykam, J. F., Gage, D. A., Clemo, H. F., Baumgarten, C. M., and Sachs, F. (2000) J. Gen. Physiol. 115, 583-598). Inhibition of cationic MSCs by the higher affinity GsMtx-4 (K(D) approximately 500 nm) reduced cell size in swollen and hypertrophic heart cells, swelling-activated currents in astrocytes, and stretch-induced arrhythmias in the heart. Despite the relatively low affinity, no cross-reactivity has been found with other channels. Using two-dimensional NMR spectroscopy, we determined the solution structure of GsMTx-4 and a lower affinity (GsMTx-2; K(D) approximately 6 microm) peptide from the same venom. The dominant feature of the two structures is a hydrophobic patch, utilizing most of the aromatic residues and surrounded with charged residues. The spatial arrangement of charged residues that are unique to GsMTx-4 and GsMTx-2 may underlie the selectivity of these peptides.
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===Solution structure of a toxin (GsMTx2) from the tarantula, Grammostola spatulata, which inhibits mechanosensitive ion channels===
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Solution structure of peptide toxins that block mechanosensitive ion channels.,Oswald RE, Suchyna TM, McFeeters R, Gottlieb P, Sachs F J Biol Chem. 2002 Sep 13;277(37):34443-50. Epub 2002 Jun 24. PMID:12082099<ref>PMID:12082099</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_12082099}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1lup" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12082099 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12082099}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Grammostola rosea]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUP OCA].
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[[Category: Large Structures]]
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[[Category: Gottlieb P]]
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==Reference==
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[[Category: McFeeters R]]
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Solution structure of peptide toxins that block mechanosensitive ion channels., Oswald RE, Suchyna TM, McFeeters R, Gottlieb P, Sachs F, J Biol Chem. 2002 Sep 13;277(37):34443-50. Epub 2002 Jun 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12082099 12082099]
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[[Category: Oswald RE]]
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[[Category: Gottlieb, P.]]
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[[Category: Sachs F]]
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[[Category: McFeeters, R.]]
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[[Category: Suchyna TM]]
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[[Category: Oswald, R E.]]
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[[Category: Sachs, F.]]
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[[Category: Suchyna, T M.]]
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[[Category: Beta-sheet]]
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[[Category: Inhibitor cysteine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:20:06 2008''
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Current revision

Solution structure of a toxin (GsMTx2) from the tarantula, Grammostola spatulata, which inhibits mechanosensitive ion channels

PDB ID 1lup

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