1mbh

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[[Image:1mbh.png|left|200px]]
 
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==MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2==
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The line below this paragraph, containing "STRUCTURE_1mbh", creates the "Structure Box" on the page.
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<StructureSection load='1mbh' size='340' side='right'caption='[[1mbh]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mbh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MBH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 50 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_1mbh| PDB=1mbh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbh OCA], [https://pdbe.org/1mbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mbh RCSB], [https://www.ebi.ac.uk/pdbsum/1mbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mbh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mb/1mbh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mbh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The DNA-binding domain of c-Myb consists of three imperfect tandem repeats (R1, R2 and R3). The three repeats have similar overall architectures, each containing a helix-turn-helix variation motif. The three conserved tryptophans in each repeat participate in forming a hydrophobic core. Comparison of the three repeat structures indicated that cavities are found in the hydrophobic core of R2, which is thermally unstable. On complexation with DNA, the orientations of R2 and R3 are fixed by tight binding and their conformations are slightly changed. No significant changes occur in the chemical shifts of R1 consistent with its loose interaction with DNA.
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===MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2===
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Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb.,Ogata K, Morikawa S, Nakamura H, Hojo H, Yoshimura S, Zhang R, Aimoto S, Ametani Y, Hirata Z, Sarai A, et al. Nat Struct Biol. 1995 Apr;2(4):309-20. PMID:7796266<ref>PMID:7796266</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1mbh" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_7796266}}, adds the Publication Abstract to the page
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 7796266 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_7796266}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1mbh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBH OCA].
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==Reference==
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<ref group="xtra">PMID:007796266</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Aimoto, S.]]
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[[Category: Aimoto S]]
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[[Category: Ametani, Y.]]
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[[Category: Ametani Y]]
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[[Category: Hirata, Z.]]
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[[Category: Hirata Z]]
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[[Category: Hojo, H.]]
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[[Category: Hojo H]]
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[[Category: Ishii, S.]]
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[[Category: Ishii S]]
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[[Category: Morikawa, S.]]
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[[Category: Morikawa S]]
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[[Category: Nakamura, H.]]
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[[Category: Nakamura H]]
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[[Category: Nishimura, Y.]]
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[[Category: Nishimura Y]]
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[[Category: Ogata, K.]]
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[[Category: Ogata K]]
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[[Category: Sarai, A.]]
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[[Category: Sarai A]]
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[[Category: Yoshimura, S.]]
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[[Category: Yoshimura S]]
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[[Category: Zhang, R.]]
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[[Category: Zhang R]]
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[[Category: Dna-binding protein]]
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[[Category: Protooncogene product]]
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Current revision

MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2

PDB ID 1mbh

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