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1md6

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==High resolution crystal structure of murine IL-1F5 reveals unique loop conformation for specificity==
==High resolution crystal structure of murine IL-1F5 reveals unique loop conformation for specificity==
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<StructureSection load='1md6' size='340' side='right' caption='[[1md6]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='1md6' size='340' side='right'caption='[[1md6]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1md6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MD6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1md6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MD6 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1md6 OCA], [http://pdbe.org/1md6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1md6 RCSB], [http://www.ebi.ac.uk/pdbsum/1md6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1md6 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1md6 OCA], [https://pdbe.org/1md6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1md6 RCSB], [https://www.ebi.ac.uk/pdbsum/1md6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1md6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I36RA_MOUSE I36RA_MOUSE]] Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response (By similarity).
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[https://www.uniprot.org/uniprot/I36RA_MOUSE I36RA_MOUSE] Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/1md6_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/1md6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Dunn, E F]]
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[[Category: Mus musculus]]
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[[Category: Gay, N J]]
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[[Category: Dunn EF]]
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[[Category: Neill, L A.O]]
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[[Category: Gay NJ]]
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[[Category: Pei, X Y]]
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[[Category: O'Neill LA]]
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[[Category: Alpha helix]]
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[[Category: Pei XY]]
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[[Category: Beta triple]]
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[[Category: Immune system]]
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Current revision

High resolution crystal structure of murine IL-1F5 reveals unique loop conformation for specificity

PDB ID 1md6

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