1ms8

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<StructureSection load='1ms8' size='340' side='right'caption='[[1ms8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1ms8' size='340' side='right'caption='[[1ms8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ms8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MS8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ms8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MS8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mr5|1mr5]], [[1ms0|1ms0]], [[1ms1|1ms1]], [[1ms3|1ms3]], [[1ms4|1ms4]], [[1ms5|1ms5]], [[1ms9|1ms9]], [[1mz5|1mz5]], [[1mz6|1mz6]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ms8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms8 OCA], [https://pdbe.org/1ms8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ms8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ms8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ms8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms8 OCA], [https://pdbe.org/1ms8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ms8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ms8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q26966_TRYCR Q26966_TRYCR]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1ms8_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1ms8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exo-alpha-sialidase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trycr]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Alzari, P M]]
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[[Category: Alzari PM]]
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[[Category: Amaya, M F]]
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[[Category: Amaya MF]]
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[[Category: Buschiazzo, A]]
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[[Category: Buschiazzo A]]
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[[Category: Cremona, M L]]
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[[Category: Cremona ML]]
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[[Category: Frasch, A C]]
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[[Category: Frasch AC]]
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[[Category: Beta-propeller]]
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[[Category: Hydrolase]]
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[[Category: Protein-carbohydrate interaction]]
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[[Category: Sialidase]]
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[[Category: Trans-glycosylation]]
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Current revision

Triclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)

PDB ID 1ms8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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