1nns

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{{Seed}}
 
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[[Image:1nns.png|left|200px]]
 
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==L-asparaginase of E. coli in C2 space group and 1.95 A resolution==
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The line below this paragraph, containing "STRUCTURE_1nns", creates the "Structure Box" on the page.
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<StructureSection load='1nns' size='340' side='right'caption='[[1nns]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nns]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NNS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene></td></tr>
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{{STRUCTURE_1nns| PDB=1nns | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nns OCA], [https://pdbe.org/1nns PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nns RCSB], [https://www.ebi.ac.uk/pdbsum/1nns PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nns ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASPG2_ECOLI ASPG2_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/1nns_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nns ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The functional L-asparaginase from Escherichia coli is a homotetramer with a molecular weight of about 142 kDa. The X-ray structure of the enzyme, crystallized in a new form (space group C2) and refined to 1.95 A resolution, is compared with that of the previously determined crystal form (space group P2(1)). The asymmetric unit of the new crystal form contains an L-asparaginase dimer instead of the tetramer found in the previous crystal form. It is found that crystal contacts practically do not affect the conformation of the protein. It is shown that subunit C of the tetrameric form is in a conformation which is systematically different from that of all other subunits in both crystal forms. Major conformational differences are confined to the lid loop (residues 14-27). In addition, the stability of this globular protein is analyzed in terms of the interactions between hydrophobic parts of the subunits.
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===L-asparaginase of E. coli in C2 space group and 1.95 A resolution===
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Structural comparison of Escherichia coli L-asparaginase in two monoclinic space groups.,Sanches M, Barbosa JA, de Oliveira RT, Abrahao Neto J, Polikarpov I Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):416-22. Epub 2003, Feb 21. PMID:12595697<ref>PMID:12595697</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1nns" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12595697}}, adds the Publication Abstract to the page
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*[[Asparaginase 3D structures|Asparaginase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12595697 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12595697}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1NNS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNS OCA].
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==Reference==
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Structural comparison of Escherichia coli L-asparaginase in two monoclinic space groups., Sanches M, Barbosa JA, de Oliveira RT, Abrahao Neto J, Polikarpov I, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):416-22. Epub 2003, Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595697 12595697]
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[[Category: Asparaginase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Barbosa, J A.R G.]]
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[[Category: Barbosa JARG]]
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[[Category: Neto, J A.A.]]
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[[Category: Neto JAA]]
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[[Category: Oliveira, R T.de.]]
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[[Category: Polikarpov I]]
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[[Category: Polikarpov, I.]]
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[[Category: Sanches M]]
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[[Category: Sanches, M.]]
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[[Category: De Oliveira RT]]
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[[Category: Amidrohydrolase]]
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[[Category: Crystallographic comparison]]
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[[Category: L-asparaginase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:55:55 2008''
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Current revision

L-asparaginase of E. coli in C2 space group and 1.95 A resolution

PDB ID 1nns

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