1oqw

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[[Image:1oqw.gif|left|200px]]
 
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{{Structure
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==Full-Length PAK Pilin from Pseudomonas aeruginosa==
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|PDB= 1oqw |SIZE=350|CAPTION= <scene name='initialview01'>1oqw</scene>, resolution 2.0&Aring;
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<StructureSection load='1oqw' size='340' side='right'caption='[[1oqw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1oqw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OQW FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqw OCA], [https://pdbe.org/1oqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oqw RCSB], [https://www.ebi.ac.uk/pdbsum/1oqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqw ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[1oqv|1OQV]], [[1or9|1OR9]], [[1dzo|1DZO]], [[2pil|2PIL]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqw OCA], [http://www.ebi.ac.uk/pdbsum/1oqw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oqw RCSB]</span>
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[https://www.uniprot.org/uniprot/FMPA_PSEAI FMPA_PSEAI]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oqw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pilin assembly into type IV pili is required for virulence by bacterial pathogens that cause diseases such as cholera, pneumonia, gonorrhea, and meningitis. Crystal structures of soluble, N-terminally truncated pilin from Vibrio cholera toxin-coregulated pilus (TCP) and full-length PAK pilin from Pseudomonas aeruginosa reveal a novel TCP fold, yet a shared architecture for the type IV pilins. In each pilin subunit a conserved, extended, N-terminal alpha helix wrapped by beta strands anchors the structurally variable globular head. Inside the assembled pilus, characterized by cryo-electron microscopy and crystallography, the extended hydrophobic alpha helices make multisubunit contacts to provide mechanical strength and flexibility. Outside, distinct interactions of adaptable heads contribute surface variation for specificity of pilus function in antigenicity, motility, adhesion, and colony formation.
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'''Full-Length PAK Pilin from Pseudomonas aeruginosa'''
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Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin.,Craig L, Taylor RK, Pique ME, Adair BD, Arvai AS, Singh M, Lloyd SJ, Shin DS, Getzoff ED, Yeager M, Forest KT, Tainer JA Mol Cell. 2003 May;11(5):1139-50. PMID:12769840<ref>PMID:12769840</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1oqw" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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Pilin assembly into type IV pili is required for virulence by bacterial pathogens that cause diseases such as cholera, pneumonia, gonorrhea, and meningitis. Crystal structures of soluble, N-terminally truncated pilin from Vibrio cholera toxin-coregulated pilus (TCP) and full-length PAK pilin from Pseudomonas aeruginosa reveal a novel TCP fold, yet a shared architecture for the type IV pilins. In each pilin subunit a conserved, extended, N-terminal alpha helix wrapped by beta strands anchors the structurally variable globular head. Inside the assembled pilus, characterized by cryo-electron microscopy and crystallography, the extended hydrophobic alpha helices make multisubunit contacts to provide mechanical strength and flexibility. Outside, distinct interactions of adaptable heads contribute surface variation for specificity of pilus function in antigenicity, motility, adhesion, and colony formation.
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*[[Pilin 3D structures|Pilin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1OQW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQW OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin., Craig L, Taylor RK, Pique ME, Adair BD, Arvai AS, Singh M, Lloyd SJ, Shin DS, Getzoff ED, Yeager M, Forest KT, Tainer JA, Mol Cell. 2003 May;11(5):1139-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12769840 12769840]
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[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Single protein]]
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[[Category: Arvai AS]]
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[[Category: Arvai, A S.]]
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[[Category: Craig L]]
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[[Category: Craig, L.]]
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[[Category: Forest KT]]
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[[Category: Forest, K T.]]
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[[Category: Tainer JA]]
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[[Category: Tainer, J A.]]
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[[Category: adhesion]]
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[[Category: fiber-forming protein]]
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[[Category: pak pilin]]
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[[Category: pseudomonas aerugionosa]]
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[[Category: type iv pilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:49:05 2008''
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Current revision

Full-Length PAK Pilin from Pseudomonas aeruginosa

PDB ID 1oqw

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