1rpy

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{{Seed}}
 
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[[Image:1rpy.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS==
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The line below this paragraph, containing "STRUCTURE_1rpy", creates the "Structure Box" on the page.
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<StructureSection load='1rpy' size='340' side='right'caption='[[1rpy]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rpy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RPY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1rpy| PDB=1rpy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpy OCA], [https://pdbe.org/1rpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rpy RCSB], [https://www.ebi.ac.uk/pdbsum/1rpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SH2B2_RAT SH2B2_RAT] Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis (By similarity). Involved in stimulation of glucose uptake by insulin. Involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Induces cytoskeletal reorganization and neurite outgrowth in cultured neurons.<ref>PMID:9856458</ref> <ref>PMID:10854852</ref> <ref>PMID:11997497</ref> <ref>PMID:15031295</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rp/1rpy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rpy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The adaptor protein APS is a substrate of the insulin receptor and couples receptor activation with phosphorylation of Cbl to facilitate glucose uptake. The interaction with the activated insulin receptor is mediated by the Src homology 2 (SH2) domain of APS. Here, we present the crystal structure of the APS SH2 domain in complex with the phosphorylated tyrosine kinase domain of the insulin receptor. The structure reveals a novel dimeric configuration of the APS SH2 domain, wherein the C-terminal half of each protomer is structurally divergent from conventional, monomeric SH2 domains. The APS SH2 dimer engages two kinase molecules, with pTyr-1158 of the kinase activation loop bound in the canonical phosphotyrosine binding pocket of the SH2 domain and a second phosphotyrosine, pTyr-1162, coordinated by two lysine residues in beta strand D. This structure provides a molecular visualization of one of the initial downstream recruitment events following insulin activation of its dimeric receptor.
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===CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS===
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Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.,Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR Mol Cell. 2003 Dec;12(6):1379-89. PMID:14690593<ref>PMID:14690593</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14690593}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1rpy" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14690593 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14690593}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1RPY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPY OCA].
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==Reference==
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<ref group="xtra">PMID:14690593</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Ghirlando, R.]]
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[[Category: Ghirlando R]]
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[[Category: Hu, J.]]
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[[Category: Hu J]]
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[[Category: Hubbard, S R.]]
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[[Category: Hubbard SR]]
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[[Category: Liu, J.]]
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[[Category: Liu J]]
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[[Category: Saltiel, A R.]]
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[[Category: Saltiel AR]]
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[[Category: Adapter protein]]
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[[Category: Sh2 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:45:47 2009''
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Current revision

CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS

PDB ID 1rpy

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