1vgn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:33, 30 October 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1vgn.gif|left|200px]]<br /><applet load="1vgn" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1vgn, resolution 2.63&Aring;" />
 
-
'''Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)'''<br />
 
-
==About this Structure==
+
==Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)==
-
1VGN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=OPS:'>OPS</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGN OCA].
+
<StructureSection load='1vgn' size='340' side='right'caption='[[1vgn]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1vgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VGN FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=OPS:3-OXO-3-[(3-OXOPROPYL)SULFANYL]PROPANE-1-THIOLATE'>OPS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgn OCA], [https://pdbe.org/1vgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vgn RCSB], [https://www.ebi.ac.uk/pdbsum/1vgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgn ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vg/1vgn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vgn ConSurf].
 +
<div style="clear:both"></div>
-
==Reference==
+
==See Also==
-
Irreversible inhibition of metallo-beta-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester., Kurosaki H, Yamaguchi Y, Higashi T, Soga K, Matsueda S, Yumoto H, Misumi S, Yamagata Y, Arakawa Y, Goto M, Angew Chem Int Ed Engl. 2005 Jun 20;44(25):3861-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15892033 15892033]
+
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
-
[[Category: Beta-lactamase]]
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Serratia marcescens]]
[[Category: Serratia marcescens]]
-
[[Category: Single protein]]
+
[[Category: Arakawa Y]]
-
[[Category: Arakawa, Y.]]
+
[[Category: Goto M]]
-
[[Category: Goto, M.]]
+
[[Category: Higashi T]]
-
[[Category: Higashi, T.]]
+
[[Category: Kurosaki H]]
-
[[Category: Kurosaki, H.]]
+
[[Category: Matsueda S]]
-
[[Category: Matsueda, S.]]
+
[[Category: Misumi S]]
-
[[Category: Misumi, S.]]
+
[[Category: Soga K]]
-
[[Category: Soga, K.]]
+
[[Category: Yamagata Y]]
-
[[Category: Yamagata, Y.]]
+
[[Category: Yamaguchi Y]]
-
[[Category: Yamaguchi, Y.]]
+
-
[[Category: ACY]]
+
-
[[Category: OPS]]
+
-
[[Category: ZN]]
+
-
[[Category: irreversible inhibitor]]
+
-
[[Category: metallo-beta-lactamase]]
+
-
[[Category: zinc]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:35:11 2008''
+

Current revision

Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)

PDB ID 1vgn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vgn"
Personal tools