1vgn

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{{Seed}}
 
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[[Image:1vgn.png|left|200px]]
 
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==Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)==
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The line below this paragraph, containing "STRUCTURE_1vgn", creates the "Structure Box" on the page.
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<StructureSection load='1vgn' size='340' side='right'caption='[[1vgn]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VGN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=OPS:3-OXO-3-[(3-OXOPROPYL)SULFANYL]PROPANE-1-THIOLATE'>OPS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1vgn| PDB=1vgn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgn OCA], [https://pdbe.org/1vgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vgn RCSB], [https://www.ebi.ac.uk/pdbsum/1vgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vg/1vgn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vgn ConSurf].
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<div style="clear:both"></div>
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===Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)===
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1VGN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGN OCA].
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[[Category: Large Structures]]
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==Reference==
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Irreversible inhibition of metallo-beta-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester., Kurosaki H, Yamaguchi Y, Higashi T, Soga K, Matsueda S, Yumoto H, Misumi S, Yamagata Y, Arakawa Y, Goto M, Angew Chem Int Ed Engl. 2005 Jun 20;44(25):3861-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15892033 15892033]
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[[Category: Beta-lactamase]]
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[[Category: Serratia marcescens]]
[[Category: Serratia marcescens]]
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[[Category: Single protein]]
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[[Category: Arakawa Y]]
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[[Category: Arakawa, Y.]]
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[[Category: Goto M]]
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[[Category: Goto, M.]]
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[[Category: Higashi T]]
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[[Category: Higashi, T.]]
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[[Category: Kurosaki H]]
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[[Category: Kurosaki, H.]]
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[[Category: Matsueda S]]
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[[Category: Matsueda, S.]]
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[[Category: Misumi S]]
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[[Category: Misumi, S.]]
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[[Category: Soga K]]
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[[Category: Soga, K.]]
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[[Category: Yamagata Y]]
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[[Category: Yamagata, Y.]]
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[[Category: Yamaguchi Y]]
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[[Category: Yamaguchi, Y.]]
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[[Category: Irreversible inhibitor]]
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[[Category: Metallo-beta-lactamase]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:55:33 2008''
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Current revision

Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)

PDB ID 1vgn

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