1xe5
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1xe5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xe5, resolution 2.4Å" /> '''Structure of plasmeps...) |
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| - | [[Image:1xe5.gif|left|200px]]<br /><applet load="1xe5" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1xe5, resolution 2.4Å" /> | ||
| - | '''Structure of plasmepsin II in complex of an pepstatin analogue'''<br /> | ||
| - | == | + | ==Structure of plasmepsin II in complex of an pepstatin analogue== |
| - | + | <StructureSection load='1xe5' size='340' side='right'caption='[[1xe5]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | [[ | + | == Structural highlights == |
| - | [ | + | <table><tr><td colspan='2'>[[1xe5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XE5 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5FE:5,5,5-TRIFLUORO-3-HYDROXY-4-[2-(5,5,5-TRIFLUORO-3-HYDROXY-4-{3-METHYL-2-[3-METHYL-2-(3-METHYL-BUTYRYLAMINO)-BUTYRYLAMINO]-BUTYRYLAMINO}-PENTANOYLAMINO)-PROPIONYLAMINO]-PENTANOIC+ACID+METHYL+ESTER'>5FE</scene></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xe5 OCA], [https://pdbe.org/1xe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xe5 RCSB], [https://www.ebi.ac.uk/pdbsum/1xe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xe5 ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PLM2_PLAFX PLM2_PLAFX] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:11782538, PubMed:15574427, PubMed:8844673). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).<ref>PMID:11782538</ref> <ref>PMID:15574427</ref> <ref>PMID:8844673</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xe5_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xe5 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Plasmepsin|Plasmepsin]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Plasmodium falciparum]] | ||
| + | [[Category: Prade L]] | ||
Current revision
Structure of plasmepsin II in complex of an pepstatin analogue
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