1tx7

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[[Image:1tx7.gif|left|200px]]
[[Image:1tx7.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1tx7 |SIZE=350|CAPTION= <scene name='initialview01'>1tx7</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1tx7", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=4CM:(4-CARBAMIMIDOYLPHENYL)-METHYL-PHOSPHINIC+ACID'>4CM</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1tx7| PDB=1tx7 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tx7 OCA], [http://www.ebi.ac.uk/pdbsum/1tx7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tx7 RCSB]</span>
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}}
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'''Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)'''
'''Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)'''
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[[Category: Marankan, F.]]
[[Category: Marankan, F.]]
[[Category: Mesecar, A.]]
[[Category: Mesecar, A.]]
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[[Category: bovine]]
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[[Category: Bovine]]
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[[Category: p-amidinophenylmethylphosphinic acid (ampa)]]
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[[Category: Trypsin]]
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[[Category: trypsin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:28:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:02:23 2008''
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Revision as of 07:28, 3 May 2008

Image:1tx7.gif

Template:STRUCTURE 1tx7

Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)


Overview

p-amidinophenylmethylphosphinic acid (AMPA) was designed, synthesized and crystallized in complex with trypsin to study interactions with the oxyanion hole at the S1 site. In comparison to benzamidine, AMPA shows improved activity, which the crystal structure demonstrates to result from hydrogen bonds between the negatively charged phosphinic acid group and the catalytic residues at the oxyanion hole.

About this Structure

1TX7 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

An oxyanion-hole selective serine protease inhibitor in complex with trypsin., Cui J, Marankan F, Fu W, Crich D, Mesecar A, Johnson ME, Bioorg Med Chem. 2002 Jan;10(1):41-6. PMID:11738605 Page seeded by OCA on Sat May 3 10:28:41 2008

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OCA

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