1z3g

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[[Image:1z3g.gif|left|200px]]<br /><applet load="1z3g" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1z3g, resolution 3.3&Aring;" />
 
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'''Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8'''<br />
 
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==Overview==
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==Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8==
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<StructureSection load='1z3g' size='340' side='right'caption='[[1z3g]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z3g]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_vivax_Sal-1 Plasmodium vivax Sal-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3g OCA], [https://pdbe.org/1z3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3g RCSB], [https://www.ebi.ac.uk/pdbsum/1z3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O96555_PLAVI O96555_PLAVI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3g ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
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==About this Structure==
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The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms.,Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807<ref>PMID:16327807</ref>
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1Z3G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3G OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16327807 16327807]
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</div>
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[[Category: Mus musculus]]
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<div class="pdbe-citations 1z3g" style="background-color:#fffaf0;"></div>
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[[Category: Plasmodium vivax]]
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[[Category: Single protein]]
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[[Category: Garboczi, D N.]]
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[[Category: Klein, M M.]]
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[[Category: Long, C A.]]
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[[Category: Saul, A J.]]
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[[Category: Saxena, A K.]]
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[[Category: Singh, K.]]
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[[Category: Stowers, A W.]]
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[[Category: Su, H P.]]
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[[Category: 2a8 fab]]
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[[Category: pvs25]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:11:43 2008''
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Plasmodium vivax Sal-1]]
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[[Category: Garboczi DN]]
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[[Category: Klein MM]]
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[[Category: Long CA]]
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[[Category: Saul AJ]]
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[[Category: Saxena AK]]
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[[Category: Singh K]]
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[[Category: Stowers AW]]
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[[Category: Su HP]]

Current revision

Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8

PDB ID 1z3g

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