2dcc

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[[Image:2dcc.gif|left|200px]]
 
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{{Structure
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==X-ray crystal structure analysis of bovine spleen cathepsin B-CA077 complex==
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|PDB= 2dcc |SIZE=350|CAPTION= <scene name='initialview01'>2dcc</scene>, resolution 1.93&Aring;
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<StructureSection load='2dcc' size='340' side='right'caption='[[2dcc]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=77B:BENZYL+N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE'>77B</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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<table><tr><td colspan='2'>[[2dcc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DCC FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=77B:BENZYL+N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE'>77B</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dcc OCA], [https://pdbe.org/2dcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dcc RCSB], [https://www.ebi.ac.uk/pdbsum/2dcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dcc ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1ito|1ITO]], [[1qdq|1QDQ]], [[2dc6|2DC6]], [[2dc7|2DC7]], [[2dc8|2DC8]], [[2dc9|2DC9]], [[2dca|2DCA]], [[2dcb|2DCB]], [[2dcd|2DCD]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dcc OCA], [http://www.ebi.ac.uk/pdbsum/2dcc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dcc RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CATB_BOVIN CATB_BOVIN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/2dcc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dcc ConSurf].
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<div style="clear:both"></div>
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'''X-ray crystal structure analysis of bovine spleen cathepsin B-CA077 complex'''
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==See Also==
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2DCC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DCC OCA].
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Cathepsin B]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Watanabe D]]
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[[Category: Watanabe, D.]]
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[[Category: ca077]]
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[[Category: cathepsin b]]
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[[Category: cysteine protease]]
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[[Category: ec 3 4.22 1]]
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[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:32:48 2008''
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Current revision

X-ray crystal structure analysis of bovine spleen cathepsin B-CA077 complex

PDB ID 2dcc

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