2e5e

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{{Seed}}
 
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[[Image:2e5e.png|left|200px]]
 
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==Solution Structure of Variable-type Domain of Human Receptor for Advanced Glycation Endproducts==
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The line below this paragraph, containing "STRUCTURE_2e5e", creates the "Structure Box" on the page.
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<StructureSection load='2e5e' size='340' side='right'caption='[[2e5e]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2e5e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5e OCA], [https://pdbe.org/2e5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5e RCSB], [https://www.ebi.ac.uk/pdbsum/2e5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5e ProSAT]</span></td></tr>
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{{STRUCTURE_2e5e| PDB=2e5e | SCENE= }}
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</table>
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== Function ==
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===Solution Structure of Variable-type Domain of Human Receptor for Advanced Glycation Endproducts===
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[https://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2E5E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5E OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5e ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kobayashi, Y.]]
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[[Category: Kobayashi Y]]
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[[Category: Matsumoto, S.]]
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[[Category: Matsumoto S]]
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[[Category: Ohkubo, T.]]
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[[Category: Ohkubo T]]
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[[Category: Yamamoto, H.]]
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[[Category: Yamamoto H]]
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[[Category: Yasumatsu, I.]]
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[[Category: Yasumatsu I]]
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[[Category: Yoshida, T.]]
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[[Category: Yoshida T]]
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[[Category: Signaling protein]]
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[[Category: Variable-type immunoglobulin-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 9 10:03:44 2008''
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Current revision

Solution Structure of Variable-type Domain of Human Receptor for Advanced Glycation Endproducts

PDB ID 2e5e

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